Molecular mechanisms of antibiotic resistance

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Molecular mechanisms of antibiotic resistance. / Blair, Jessica M A; Webber, Mark A; Baylay, Alison J; Ogbolu, David O; Piddock, Laura J V.

In: Nature Reviews Microbiology, Vol. 13, No. 1, 01.2015, p. 42-51.

Research output: Contribution to journalArticle

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@article{16be5b85f17a467eb89b274e79476a59,
title = "Molecular mechanisms of antibiotic resistance",
abstract = "Antibiotic-resistant bacteria that are difficult or impossible to treat are becoming increasingly common and are causing a global health crisis. Antibiotic resistance is encoded by several genes, many of which can transfer between bacteria. New resistance mechanisms are constantly being described, and new genes and vectors of transmission are identified on a regular basis. This article reviews recent advances in our understanding of the mechanisms by which bacteria are either intrinsically resistant or acquire resistance to antibiotics, including the prevention of access to drug targets, changes in the structure and protection of antibiotic targets and the direct modification or inactivation of antibiotics.",
author = "Blair, {Jessica M A} and Webber, {Mark A} and Baylay, {Alison J} and Ogbolu, {David O} and Piddock, {Laura J V}",
year = "2015",
month = jan
doi = "10.1038/nrmicro3380",
language = "English",
volume = "13",
pages = "42--51",
journal = "Nature Reviews Microbiology",
issn = "1740-1526",
publisher = "Nature Publishing Group",
number = "1",

}

RIS

TY - JOUR

T1 - Molecular mechanisms of antibiotic resistance

AU - Blair, Jessica M A

AU - Webber, Mark A

AU - Baylay, Alison J

AU - Ogbolu, David O

AU - Piddock, Laura J V

PY - 2015/1

Y1 - 2015/1

N2 - Antibiotic-resistant bacteria that are difficult or impossible to treat are becoming increasingly common and are causing a global health crisis. Antibiotic resistance is encoded by several genes, many of which can transfer between bacteria. New resistance mechanisms are constantly being described, and new genes and vectors of transmission are identified on a regular basis. This article reviews recent advances in our understanding of the mechanisms by which bacteria are either intrinsically resistant or acquire resistance to antibiotics, including the prevention of access to drug targets, changes in the structure and protection of antibiotic targets and the direct modification or inactivation of antibiotics.

AB - Antibiotic-resistant bacteria that are difficult or impossible to treat are becoming increasingly common and are causing a global health crisis. Antibiotic resistance is encoded by several genes, many of which can transfer between bacteria. New resistance mechanisms are constantly being described, and new genes and vectors of transmission are identified on a regular basis. This article reviews recent advances in our understanding of the mechanisms by which bacteria are either intrinsically resistant or acquire resistance to antibiotics, including the prevention of access to drug targets, changes in the structure and protection of antibiotic targets and the direct modification or inactivation of antibiotics.

U2 - 10.1038/nrmicro3380

DO - 10.1038/nrmicro3380

M3 - Article

C2 - 25435309

VL - 13

SP - 42

EP - 51

JO - Nature Reviews Microbiology

JF - Nature Reviews Microbiology

SN - 1740-1526

IS - 1

ER -