Molecular mechanisms of antibiotic resistance

Research output: Contribution to journalArticle

Authors

Colleges, School and Institutes

Abstract

Antibiotic-resistant bacteria that are difficult or impossible to treat are becoming increasingly common and are causing a global health crisis. Antibiotic resistance is encoded by several genes, many of which can transfer between bacteria. New resistance mechanisms are constantly being described, and new genes and vectors of transmission are identified on a regular basis. This article reviews recent advances in our understanding of the mechanisms by which bacteria are either intrinsically resistant or acquire resistance to antibiotics, including the prevention of access to drug targets, changes in the structure and protection of antibiotic targets and the direct modification or inactivation of antibiotics.

Details

Original languageEnglish
Pages (from-to)42-51
Number of pages10
JournalNature Reviews Microbiology
Volume13
Issue number1
Publication statusPublished - Jan 2015