Molecular boronic acid-based saccharide sensors

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Molecular boronic acid-based saccharide sensors. / Williams, George T.; Kedge, Jonathan L.; Fossey, John S.

In: ACS Sensors, Vol. 6, No. 4, 23.04.2021, p. 1508–1528.

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@article{4a4ab208184f4c25b12cf8ae75ac00da,
title = "Molecular boronic acid-based saccharide sensors",
abstract = "Boronic acids can reversibly bind diols, a molecular feature that is ubiquitous within saccharides, leading to their use in the design and implementation of sensors for numerous saccharide species. There is a growing understanding of the importance of saccharides in many biological processes and systems; while saccharide or carbohydrate sensing in medicine is most often associated with detection of glucose in diabetes patients, saccharides have proven to be relevant in a range of disease states. Herein the relevance of carbohydrate sensing for biomedical applications is explored, and this review seeks to outline how the complexity of saccharides presents a challenge for the development of selective sensors and describes efforts that have been made to understand the underpinning fluorescence and binding mechanisms of these systems, before outlining examples of how researchers have used this knowledge to develop ever more selective receptors.",
keywords = "carbohydrate, fluorescence, electrochemical, colorimetric, diabetes, biomarker, boronic acids, hydrogels, glucose",
author = "Williams, {George T.} and Kedge, {Jonathan L.} and Fossey, {John S.}",
year = "2021",
month = apr,
day = "23",
doi = "10.1021/acssensors.1c00462",
language = "English",
volume = "6",
pages = "1508–1528",
journal = "ACS Sensors",
publisher = "American Chemical Society",
number = "4",

}

RIS

TY - JOUR

T1 - Molecular boronic acid-based saccharide sensors

AU - Williams, George T.

AU - Kedge, Jonathan L.

AU - Fossey, John S.

PY - 2021/4/23

Y1 - 2021/4/23

N2 - Boronic acids can reversibly bind diols, a molecular feature that is ubiquitous within saccharides, leading to their use in the design and implementation of sensors for numerous saccharide species. There is a growing understanding of the importance of saccharides in many biological processes and systems; while saccharide or carbohydrate sensing in medicine is most often associated with detection of glucose in diabetes patients, saccharides have proven to be relevant in a range of disease states. Herein the relevance of carbohydrate sensing for biomedical applications is explored, and this review seeks to outline how the complexity of saccharides presents a challenge for the development of selective sensors and describes efforts that have been made to understand the underpinning fluorescence and binding mechanisms of these systems, before outlining examples of how researchers have used this knowledge to develop ever more selective receptors.

AB - Boronic acids can reversibly bind diols, a molecular feature that is ubiquitous within saccharides, leading to their use in the design and implementation of sensors for numerous saccharide species. There is a growing understanding of the importance of saccharides in many biological processes and systems; while saccharide or carbohydrate sensing in medicine is most often associated with detection of glucose in diabetes patients, saccharides have proven to be relevant in a range of disease states. Herein the relevance of carbohydrate sensing for biomedical applications is explored, and this review seeks to outline how the complexity of saccharides presents a challenge for the development of selective sensors and describes efforts that have been made to understand the underpinning fluorescence and binding mechanisms of these systems, before outlining examples of how researchers have used this knowledge to develop ever more selective receptors.

KW - carbohydrate

KW - fluorescence

KW - electrochemical

KW - colorimetric

KW - diabetes

KW - biomarker

KW - boronic acids

KW - hydrogels

KW - glucose

U2 - 10.1021/acssensors.1c00462

DO - 10.1021/acssensors.1c00462

M3 - Article

C2 - 33844515

VL - 6

SP - 1508

EP - 1528

JO - ACS Sensors

JF - ACS Sensors

IS - 4

ER -