Modulation of endothelial responses by the stromal microenvironment: effects on leucocyte recruitment

Research output: Contribution to journalArticle

Abstract

Vascular endothelial cells play a pivotal role in regulating leucocyte recruitment during inflammation, and their responses can be modulated by their local environment, including cells of the tissue stroma. We have developed a model system to examine how the communication between endothelial cells and fibroblasts regulates the recruitment of leucocytes and their subsequent subendothelial fate. Here, we describe a novel co-culture filter-based flow assay and highlight the ability of synovial fibroblasts obtained from chronically inflamed tissue to promote leucocyte recruitment to otherwise 'resting' endothelial cells.

Details

Original languageEnglish
Pages (from-to)1161-1162
Number of pages2
JournalBiochemical Society Transactions
Volume35
Issue number5
Publication statusPublished - 1 Oct 2007

Keywords

  • leucocyte, endothelial cell, stromal cell, neutrophil, fibroblast, adhesion