Modular Synthesis of Diverse Natural Product-like Macrocycles: Discovery of Hits with Antimycobacterial Activity

Research output: Contribution to journalArticle

Authors

  • Mark Dow
  • Fransceco Marchetti
  • Luis Vaz
  • Stuart Warriner

Colleges, School and Institutes

Abstract

A modular synthetic approach was developed in which variation of the triplets of building blocks used enabled systematic variation of the macrocyclic scaffolds prepared. The approach was demonstrated in the synthesis of 17 diverse natural product-like macrocyclic scaffolds of varied (12-20-membered) ring size. The biological relevance of the chemical space explored was demonstrated through the discovery of a series of macrocycles with significant antimycobacterial activity.

Details

Original languageEnglish
JournalChemistry: A European Journal
Early online date4 Apr 2017
Publication statusE-pub ahead of print - 4 Apr 2017

Keywords

  • Journal Article