Modular Design of the Selectivity Filter Pore Loop in a Novel Family of Prokaryotic 'Inward Rectifier' (NirBac) channels

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Modular Design of the Selectivity Filter Pore Loop in a Novel Family of Prokaryotic 'Inward Rectifier' (NirBac) channels. / Zubcevic, Lejla; Wang, Shizhen; Bavro, Vassiliy N; Lee, Sun-Joo; Nichols, Colin G; Tucker, Stephen J.

In: Scientific Reports, Vol. 5, 15305, 16.10.2015.

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Zubcevic, Lejla ; Wang, Shizhen ; Bavro, Vassiliy N ; Lee, Sun-Joo ; Nichols, Colin G ; Tucker, Stephen J. / Modular Design of the Selectivity Filter Pore Loop in a Novel Family of Prokaryotic 'Inward Rectifier' (NirBac) channels. In: Scientific Reports. 2015 ; Vol. 5.

Bibtex

@article{40faa90bd2f9452c8389ea32b67522be,
title = "Modular Design of the Selectivity Filter Pore Loop in a Novel Family of Prokaryotic 'Inward Rectifier' (NirBac) channels",
abstract = "Potassium channels exhibit a modular design with distinct structural and functional domains; in particular, a highly conserved pore-loop sequence that determines their ionic selectivity. We now report the functional characterisation of a novel group of functionally non-selective members of the prokaryotic 'inward rectifier' subfamily of K(+) channels. These channels share all the key structural domains of eukaryotic and prokaryotic Kir/KirBac channels, but instead possess unique pore-loop selectivity filter sequences unrelated to any other known ionic selectivity filter. The strikingly unusual architecture of these 'NirBac' channels defines a new family of functionally non-selective ion channels, and also provides important insights into the modular design of ion channels, as well as the evolution of ionic selectivity within this superfamily of tetrameric cation channels.",
author = "Lejla Zubcevic and Shizhen Wang and Bavro, {Vassiliy N} and Sun-Joo Lee and Nichols, {Colin G} and Tucker, {Stephen J}",
year = "2015",
month = oct,
day = "16",
doi = "10.1038/srep15305",
language = "English",
volume = "5",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",

}

RIS

TY - JOUR

T1 - Modular Design of the Selectivity Filter Pore Loop in a Novel Family of Prokaryotic 'Inward Rectifier' (NirBac) channels

AU - Zubcevic, Lejla

AU - Wang, Shizhen

AU - Bavro, Vassiliy N

AU - Lee, Sun-Joo

AU - Nichols, Colin G

AU - Tucker, Stephen J

PY - 2015/10/16

Y1 - 2015/10/16

N2 - Potassium channels exhibit a modular design with distinct structural and functional domains; in particular, a highly conserved pore-loop sequence that determines their ionic selectivity. We now report the functional characterisation of a novel group of functionally non-selective members of the prokaryotic 'inward rectifier' subfamily of K(+) channels. These channels share all the key structural domains of eukaryotic and prokaryotic Kir/KirBac channels, but instead possess unique pore-loop selectivity filter sequences unrelated to any other known ionic selectivity filter. The strikingly unusual architecture of these 'NirBac' channels defines a new family of functionally non-selective ion channels, and also provides important insights into the modular design of ion channels, as well as the evolution of ionic selectivity within this superfamily of tetrameric cation channels.

AB - Potassium channels exhibit a modular design with distinct structural and functional domains; in particular, a highly conserved pore-loop sequence that determines their ionic selectivity. We now report the functional characterisation of a novel group of functionally non-selective members of the prokaryotic 'inward rectifier' subfamily of K(+) channels. These channels share all the key structural domains of eukaryotic and prokaryotic Kir/KirBac channels, but instead possess unique pore-loop selectivity filter sequences unrelated to any other known ionic selectivity filter. The strikingly unusual architecture of these 'NirBac' channels defines a new family of functionally non-selective ion channels, and also provides important insights into the modular design of ion channels, as well as the evolution of ionic selectivity within this superfamily of tetrameric cation channels.

U2 - 10.1038/srep15305

DO - 10.1038/srep15305

M3 - Article

C2 - 26470642

VL - 5

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 15305

ER -