Modelling the complex exposure history of smoking in predicting bladder cancer: a pooled analysis of 15 case-control studies

Frits Van Osch; Jelle Vlaanderen; Sylvia Jochems; Christina Bosetti; Jerry Polesel; Stefano Porru; Angela Carta; Klaus Golka; Xuejuan Jiang; Mariana Stern; Wei-De Zhong; Eliane Kellen; Hermann Pohlabeln; Li Tang; James Marshall; Gunnar Steineck; Margaret Karagas; Kenneth Johnson; Zuo-Feng Zhang; Jack Taylor; Carlo La Vecchia; Richard Bryan; Frederik-Jan  van Schooten; Anke Wesselius; Maurice Zeegers

doi:10.1097/EDE.0000000000000964

Modelling the complex exposure history of smoking in predicting bladder cancer: a pooled analysis of 15 case-control studies

Frits Van Osch, Jelle Vlaanderen, Sylvia Jochems, Christina Bosetti, Jerry Polesel, Stefano Porru, Angela Carta, Klaus Golka, Xuejuan Jiang, Mariana Stern, Wei-De Zhong, Eliane Kellen, Hermann Pohlabeln, Li Tang, James Marshall, Gunnar Steineck, Margaret Karagas, Kenneth Johnson, Zuo-Feng Zhang, Jack TaylorCarlo La Vecchia, Richard Bryan, Frederik-Jan van Schooten, Anke Wesselius, Maurice Zeegers

Cancer and Genomic Sciences

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Abstract

Background: Few studies have modeled smoking histories by combining smoking intensity and duration to show what profile of smoking behavior is associated with highest risk of bladder cancer. This study aims to provide insight into the association between smoking exposure history and bladder cancer risk by modeling both smoking intensity and duration in a pooled analysis.

Methods: We used data from 15 case–control studies included in the BLadder cancer Epidemiology and Nutritional Determinants (BLEND) study, including a total of 6,874 cases and 17,727 controls. To jointly interpret the effects of intensity and duration of smoking, we modeled excess odds ratios (EOR) per pack–year by intensity continuously to estimate the risk difference between smokers with long duration/low intensity and short duration/high intensity.

Results: The pattern observed from the pooled EOR model indicated that for a fixed number of pack–years, smoking for a longer duration at lower intensity was more deleterious for bladder cancer risk than smoking more cigarettes/day for a shorter duration. We observed similar patterns within individual study samples.

Conclusions: This pooled analysis shows that long duration/low intensity smoking is associated with a greater increase in bladder cancer risk than short duration/ high intensity smoking within equal pack–year categories, thus confirming studies in other smoking-related cancers and demonstrating that reducing exposure history to a single metric such as pack–years was too restrictive.

Original language	English
Pages (from-to)	458-465
Number of pages	8
Journal	Epidemiology
Volume	30
Issue number	3
Early online date	26 Dec 2018
DOIs	https://doi.org/10.1097/EDE.0000000000000964
Publication status	Published - May 2019

Keywords

bladder cancer
smoking history
pooled analysis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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van_Osch_et_al_Modelling the complex exposure history_Epidemiology_2018
Published in Epidemiology on 26/12/2018 doi: 10.1097/EDE.0000000000000964 Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.
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3 Citations
4 Article

Tar, nicotine and carbon monoxide yield of UK cigarettes and the risk of non-muscle-invasive and muscle-invasive bladder cancer
Van Osch, F., Pauwels, C., Jochems, S., Fayokun, R., James, N., Wallace, D. M. A., Cheng, KK., Bryan, R., van Schooten, F. J. & Zeegers, M., Jan 2019, In: European Journal of Cancer Prevention. 28, 1, p. 40-44
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5109 Downloads (Pure)
International pooled study on diet and bladder cancer: the bladder cancer, epidemiology and nutritional determinants (BLEND) study: design and baseline characteristics
Goossens, M. E., Isa, F., Brinkman, M., Mak, D., Reulen, R., Wesselius, A., Benhamou, S., Bosetti, C., Bueno-de-Mesquita, B., Carta, A., Allam, M. F., Golka, K., Grant, E. J., Jiang, X., Johnson, K. C., Karagas, M. R., Kellen, E., La Vecchia, C., Lu, C-M., Marshall, J., & 16 othersMoysich, K., Pohlabeln, H., Porru, S., Steineck, G., Stern, M. C., Tang, L., Taylor, J. A., van den Brandt, P., Villeneuve, P. J., Wakai, K., Weiderpass, E., White, E., Wolk, A., Zhang, Z-F., Buntinx, F. & Zeegers, M. P., 6 Jul 2016, In: Archives of Public Health. 74, p. 30
Research output: Contribution to journal › Article › peer-review

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14 Citations (Scopus)
Quantified relations between exposure to tobacco smoking and bladder cancer risk: a meta-analysis of 89 observational studies
Van Osch, F., Jochems, S., van Schooten, F. J., Bryan, R. & Zeegers, M., Jun 2016, In: International Journal of Epidemiology. 45, 3, p. 857-870 14 p.
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66 Citations (Scopus)

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Significant role for lifetime cigarette smoking in worsening bladder cancer and upper tract urothelial carcinoma prognosis: a meta-analysis
van Osch, F. H. M., Jochems, S. H. J., van Schooten, F. J., Bryan, R. T. & Zeegers, M. P., 1 Apr 2016, In: Journal of Urology. 195, 4, p. 872-879
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2 Finished

Bladder Cancer Prognosis Programme
Bryan, R.
NIHR
1/05/10 → 31/07/13
Project: Other Government Departments
Recurrence and Progression of Non-Muscle-Invasive Bladder Cancer
Cheng, K., Zeegers, M., James, N., Billingham, L., Hussain, S. & Murray, P.
DUDLEY GROUP OF HOSPITALS, Cancer Research UK, NIHR
1/05/05 → 31/08/11
Project: Research

Cite this

Van Osch, F., Vlaanderen, J., Jochems, S., Bosetti, C., Polesel, J., Porru, S., Carta, A., Golka, K., Jiang, X., Stern, M., Zhong, W-D., Kellen, E., Pohlabeln, H., Tang, L., Marshall, J., Steineck, G., Karagas, M., Johnson, K., Zhang, Z-F., ... Zeegers, M. (2019). Modelling the complex exposure history of smoking in predicting bladder cancer: a pooled analysis of 15 case-control studies. Epidemiology, 30(3), 458-465. Advance online publication. https://doi.org/10.1097/EDE.0000000000000964

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abstract = "Background: Few studies have modeled smoking histories by combining smoking intensity and duration to show what profile of smoking behavior is associated with highest risk of bladder cancer. This study aims to provide insight into the association between smoking exposure history and bladder cancer risk by modeling both smoking intensity and duration in a pooled analysis.Methods: We used data from 15 case–control studies included in the BLadder cancer Epidemiology and Nutritional Determinants (BLEND) study, including a total of 6,874 cases and 17,727 controls. To jointly interpret the effects of intensity and duration of smoking, we modeled excess odds ratios (EOR) per pack–year by intensity continuously to estimate the risk difference between smokers with long duration/low intensity and short duration/high intensity.Results: The pattern observed from the pooled EOR model indicated that for a fixed number of pack–years, smoking for a longer duration at lower intensity was more deleterious for bladder cancer risk than smoking more cigarettes/day for a shorter duration. We observed similar patterns within individual study samples.Conclusions: This pooled analysis shows that long duration/low intensity smoking is associated with a greater increase in bladder cancer risk than short duration/ high intensity smoking within equal pack–year categories, thus confirming studies in other smoking-related cancers and demonstrating that reducing exposure history to a single metric such as pack–years was too restrictive.",

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Van Osch, F, Vlaanderen, J, Jochems, S, Bosetti, C, Polesel, J, Porru, S, Carta, A, Golka, K, Jiang, X, Stern, M, Zhong, W-D, Kellen, E, Pohlabeln, H, Tang, L, Marshall, J, Steineck, G, Karagas, M, Johnson, K, Zhang, Z-F, Taylor, J, La Vecchia, C, Bryan, R, van Schooten, F-J, Wesselius, A & Zeegers, M 2019, 'Modelling the complex exposure history of smoking in predicting bladder cancer: a pooled analysis of 15 case-control studies', Epidemiology, vol. 30, no. 3, pp. 458-465. https://doi.org/10.1097/EDE.0000000000000964

TY - JOUR

T1 - Modelling the complex exposure history of smoking in predicting bladder cancer

T2 - a pooled analysis of 15 case-control studies

AU - Van Osch, Frits

AU - Vlaanderen, Jelle

AU - Jochems, Sylvia

AU - Bosetti, Christina

AU - Polesel, Jerry

AU - Porru, Stefano

AU - Carta, Angela

AU - Golka, Klaus

AU - Jiang, Xuejuan

AU - Stern, Mariana

AU - Zhong, Wei-De

AU - Kellen, Eliane

AU - Pohlabeln, Hermann

AU - Tang, Li

AU - Marshall, James

AU - Steineck, Gunnar

AU - Karagas, Margaret

AU - Johnson, Kenneth

AU - Zhang, Zuo-Feng

AU - Taylor, Jack

AU - La Vecchia, Carlo

AU - Bryan, Richard

AU - van Schooten, Frederik-Jan

AU - Wesselius, Anke

AU - Zeegers, Maurice

PY - 2019/5

Y1 - 2019/5

N2 - Background: Few studies have modeled smoking histories by combining smoking intensity and duration to show what profile of smoking behavior is associated with highest risk of bladder cancer. This study aims to provide insight into the association between smoking exposure history and bladder cancer risk by modeling both smoking intensity and duration in a pooled analysis.Methods: We used data from 15 case–control studies included in the BLadder cancer Epidemiology and Nutritional Determinants (BLEND) study, including a total of 6,874 cases and 17,727 controls. To jointly interpret the effects of intensity and duration of smoking, we modeled excess odds ratios (EOR) per pack–year by intensity continuously to estimate the risk difference between smokers with long duration/low intensity and short duration/high intensity.Results: The pattern observed from the pooled EOR model indicated that for a fixed number of pack–years, smoking for a longer duration at lower intensity was more deleterious for bladder cancer risk than smoking more cigarettes/day for a shorter duration. We observed similar patterns within individual study samples.Conclusions: This pooled analysis shows that long duration/low intensity smoking is associated with a greater increase in bladder cancer risk than short duration/ high intensity smoking within equal pack–year categories, thus confirming studies in other smoking-related cancers and demonstrating that reducing exposure history to a single metric such as pack–years was too restrictive.

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KW - bladder cancer

KW - smoking history

KW - pooled analysis

U2 - 10.1097/EDE.0000000000000964

DO - 10.1097/EDE.0000000000000964

M3 - Article

SN - 1044-3983

VL - 30

SP - 458

EP - 465

JO - Epidemiology

JF - Epidemiology

IS - 3

ER -

Modelling the complex exposure history of smoking in predicting bladder cancer: a pooled analysis of 15 case-control studies

Abstract

Keywords

UN SDGs

Access to Document

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Research output

Tar, nicotine and carbon monoxide yield of UK cigarettes and the risk of non-muscle-invasive and muscle-invasive bladder cancer

International pooled study on diet and bladder cancer: the bladder cancer, epidemiology and nutritional determinants (BLEND) study: design and baseline characteristics

Quantified relations between exposure to tobacco smoking and bladder cancer risk: a meta-analysis of 89 observational studies

Significant role for lifetime cigarette smoking in worsening bladder cancer and upper tract urothelial carcinoma prognosis: a meta-analysis

Projects

Bladder Cancer Prognosis Programme

Recurrence and Progression of Non-Muscle-Invasive Bladder Cancer

Cite this