Modelling and simulation of flow and agglomeration in deep veins valves using discrete multi physics

M Ariane; W Wen; D Vigolo; A Brill; F G B Nash; M Barigou; A Alexiadis

doi:10.1016/j.compbiomed.2017.07.020

Modelling and simulation of flow and agglomeration in deep veins valves using discrete multi physics

M Ariane, W Wen, D Vigolo, A Brill, F G B Nash, M Barigou, A Alexiadis

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

324 Downloads (Pure)

Abstract

The hemodynamics in flexible deep veins valves is modelled by means of discrete multi-physics and an agglomeration algorithm is implemented to account for blood accrual in the flow. Computer simulations of a number of valves typologies are carried out. The results show that the rigidity and the length of the valve leaflets play a crucial role on both mechanical stress and stagnation in the flow. Rigid and short membranes may be inefficient in preventing blood reflux, but reduce the volume of stagnant blood potentially lowering the chances of thrombosis. Additionally, we also show that in venous valves, cell agglomeration is driven by stagnation rather than mechanical stress.

Original language	English
Pages (from-to)	96-103
Number of pages	8
Journal	Computers in Biology and Medicine
Volume	89
Early online date	29 Jul 2017
DOIs	https://doi.org/10.1016/j.compbiomed.2017.07.020
Publication status	Published - 1 Oct 2017

Keywords

Discrete multi-physics
Smoothed particle hydrodynamics
Biological venous valve
Clot
Deep venous thrombosis

Access to Document

10.1016/j.compbiomed.2017.07.020Licence: None: All rights reserved

Ariane_et_al_Modelling_and_simulation_Computers_in_Biology_and_Medicine_2017Accepted author manuscript, 730 KBLicence: Creative Commons: Attribution-NonCommercial-NoDerivs (CC BY-NC-ND)

http://www.sciencedirect.com/science/article/pii/S0010482517302445Licence: None: All rights reserved

Cite this

@article{cdce412f59544734873053d620a46560,

title = "Modelling and simulation of flow and agglomeration in deep veins valves using discrete multi physics",

abstract = "The hemodynamics in flexible deep veins valves is modelled by means of discrete multi-physics and an agglomeration algorithm is implemented to account for blood accrual in the flow. Computer simulations of a number of valves typologies are carried out. The results show that the rigidity and the length of the valve leaflets play a crucial role on both mechanical stress and stagnation in the flow. Rigid and short membranes may be inefficient in preventing blood reflux, but reduce the volume of stagnant blood potentially lowering the chances of thrombosis. Additionally, we also show that in venous valves, cell agglomeration is driven by stagnation rather than mechanical stress.",

keywords = "Discrete multi-physics, Smoothed particle hydrodynamics, Biological venous valve, Clot, Deep venous thrombosis",

author = "M Ariane and W Wen and D Vigolo and A Brill and Nash, {F G B} and M Barigou and A Alexiadis",

year = "2017",

month = oct,

day = "1",

doi = "10.1016/j.compbiomed.2017.07.020",

language = "English",

volume = "89",

pages = "96--103",

journal = "Computers in Biology and Medicine",

issn = "0010-4825",

publisher = "Elsevier",

}

TY - JOUR

T1 - Modelling and simulation of flow and agglomeration in deep veins valves using discrete multi physics

AU - Ariane, M

AU - Wen, W

AU - Vigolo, D

AU - Brill, A

AU - Nash, F G B

AU - Barigou, M

AU - Alexiadis, A

PY - 2017/10/1

Y1 - 2017/10/1

N2 - The hemodynamics in flexible deep veins valves is modelled by means of discrete multi-physics and an agglomeration algorithm is implemented to account for blood accrual in the flow. Computer simulations of a number of valves typologies are carried out. The results show that the rigidity and the length of the valve leaflets play a crucial role on both mechanical stress and stagnation in the flow. Rigid and short membranes may be inefficient in preventing blood reflux, but reduce the volume of stagnant blood potentially lowering the chances of thrombosis. Additionally, we also show that in venous valves, cell agglomeration is driven by stagnation rather than mechanical stress.

AB - The hemodynamics in flexible deep veins valves is modelled by means of discrete multi-physics and an agglomeration algorithm is implemented to account for blood accrual in the flow. Computer simulations of a number of valves typologies are carried out. The results show that the rigidity and the length of the valve leaflets play a crucial role on both mechanical stress and stagnation in the flow. Rigid and short membranes may be inefficient in preventing blood reflux, but reduce the volume of stagnant blood potentially lowering the chances of thrombosis. Additionally, we also show that in venous valves, cell agglomeration is driven by stagnation rather than mechanical stress.

KW - Discrete multi-physics

KW - Smoothed particle hydrodynamics

KW - Biological venous valve

KW - Clot

KW - Deep venous thrombosis

U2 - 10.1016/j.compbiomed.2017.07.020

DO - 10.1016/j.compbiomed.2017.07.020

M3 - Article

C2 - 28797741

SN - 0010-4825

VL - 89

SP - 96

EP - 103

JO - Computers in Biology and Medicine

JF - Computers in Biology and Medicine

ER -

Modelling and simulation of flow and agglomeration in deep veins valves using discrete multi physics

Abstract

Keywords

Access to Document

Fingerprint

Cite this