Modelling and simulation of flow and agglomeration in deep veins valves using discrete multi physics

Research output: Contribution to journalArticle

Colleges, School and Institutes

External organisations

  • University of Birmingham, Institute of Cardiovascular Sciences, City Hospital, Birmingham, United Kingdom

Abstract

The hemodynamics in flexible deep veins valves is modelled by means of discrete multi-physics and an agglomeration algorithm is implemented to account for blood accrual in the flow. Computer simulations of a number of valves typologies are carried out. The results show that the rigidity and the length of the valve leaflets play a crucial role on both mechanical stress and stagnation in the flow. Rigid and short membranes may be inefficient in preventing blood reflux, but reduce the volume of stagnant blood potentially lowering the chances of thrombosis. Additionally, we also show that in venous valves, cell agglomeration is driven by stagnation rather than mechanical stress.

Details

Original languageEnglish
Pages (from-to)96-103
Number of pages8
JournalComputers in Biology and Medicine
Volume89
Early online date29 Jul 2017
Publication statusPublished - 1 Oct 2017

Keywords

  • Discrete multi-physics, Smoothed particle hydrodynamics, Biological venous valve, Clot, Deep venous thrombosis