Mobilization of gammadelta T lymphocytes in response to psychological stress, exercise, and beta-agonist infusion

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@article{44bded0f95a84e7fb66e3813a420039d,
title = "Mobilization of gammadelta T lymphocytes in response to psychological stress, exercise, and beta-agonist infusion",
abstract = "The mobilization of cytotoxic lymphocytes, such Natural Killer (NK) cells and CD8+ T cells, during stress and exercise is well documented in humans. However, humans have another cytotoxic lymphocyte subset that has not been studied in this context: the Gamma Delta (gammadelta)T lymphocyte. These cells play key roles in immune processes including the elimination of bacterial infection, wound repair and delayed-type hypersensitivity reactions. The current study investigated the effects of stress, exercise, and beta-agonist infusion on the mobilization of gammadelta T lymphocytes. Three separate studies compared lymphocytosis in response to an acute speech stress task (n =29), high (85%Wmax) and low (35%Wmax) intensity concentric exercise (n = 11), and isoproterenol infusion at 20ng/min/kg and 40ng/min/kg (n = 12). Flow cytometric analysis was used to examine lymphocyte subsets. gammadelta T lymphocytes were mobilized in response to all three tasks in a dose-dependent manner; the extent of mobilization during the speech task correlated with concomitant cardiac activation, and was greater during higher intensity exercise and increased dose of beta-agonist infusion. The mobilization of gammadelta T lymphocytes was greater (in terms of % change from baseline) than that of CD8+ T lymphocytes and less than NK cells. This study is the first to demonstrate that gammadelta T cells are stress-responsive lymphocytes which are mobilised during psychological stress, exercise, and beta-agonist infusion. The mobilization of these versatile cytotoxic cells may provide protection in the context of situations in which antigen exposure is more likely to occur.",
keywords = "Sympathetic reactivity, Lymphocytosis, Adaptive immunity, T lymphocytes, Infusion, Exercise, Acute stress, Adrenergic, Isoproterenol, Innate immunity",
author = "K Edwards and Victoria Burns and Mark Drayson and NE Riddle and {Veldhuijzen van Zanten}, Joachimina and PJ Mills and Jos Bosch",
year = "2009",
month = mar,
day = "21",
doi = "10.1016/j.bbi.2009.03.003",
language = "English",
volume = "23",
pages = "823--829",
journal = "Brain, Behaviour, and Immunity",
issn = "0889-1591",
publisher = "Elsevier",
number = "6",

}

RIS

TY - JOUR

T1 - Mobilization of gammadelta T lymphocytes in response to psychological stress, exercise, and beta-agonist infusion

AU - Edwards, K

AU - Burns, Victoria

AU - Drayson, Mark

AU - Riddle, NE

AU - Veldhuijzen van Zanten, Joachimina

AU - Mills, PJ

AU - Bosch, Jos

PY - 2009/3/21

Y1 - 2009/3/21

N2 - The mobilization of cytotoxic lymphocytes, such Natural Killer (NK) cells and CD8+ T cells, during stress and exercise is well documented in humans. However, humans have another cytotoxic lymphocyte subset that has not been studied in this context: the Gamma Delta (gammadelta)T lymphocyte. These cells play key roles in immune processes including the elimination of bacterial infection, wound repair and delayed-type hypersensitivity reactions. The current study investigated the effects of stress, exercise, and beta-agonist infusion on the mobilization of gammadelta T lymphocytes. Three separate studies compared lymphocytosis in response to an acute speech stress task (n =29), high (85%Wmax) and low (35%Wmax) intensity concentric exercise (n = 11), and isoproterenol infusion at 20ng/min/kg and 40ng/min/kg (n = 12). Flow cytometric analysis was used to examine lymphocyte subsets. gammadelta T lymphocytes were mobilized in response to all three tasks in a dose-dependent manner; the extent of mobilization during the speech task correlated with concomitant cardiac activation, and was greater during higher intensity exercise and increased dose of beta-agonist infusion. The mobilization of gammadelta T lymphocytes was greater (in terms of % change from baseline) than that of CD8+ T lymphocytes and less than NK cells. This study is the first to demonstrate that gammadelta T cells are stress-responsive lymphocytes which are mobilised during psychological stress, exercise, and beta-agonist infusion. The mobilization of these versatile cytotoxic cells may provide protection in the context of situations in which antigen exposure is more likely to occur.

AB - The mobilization of cytotoxic lymphocytes, such Natural Killer (NK) cells and CD8+ T cells, during stress and exercise is well documented in humans. However, humans have another cytotoxic lymphocyte subset that has not been studied in this context: the Gamma Delta (gammadelta)T lymphocyte. These cells play key roles in immune processes including the elimination of bacterial infection, wound repair and delayed-type hypersensitivity reactions. The current study investigated the effects of stress, exercise, and beta-agonist infusion on the mobilization of gammadelta T lymphocytes. Three separate studies compared lymphocytosis in response to an acute speech stress task (n =29), high (85%Wmax) and low (35%Wmax) intensity concentric exercise (n = 11), and isoproterenol infusion at 20ng/min/kg and 40ng/min/kg (n = 12). Flow cytometric analysis was used to examine lymphocyte subsets. gammadelta T lymphocytes were mobilized in response to all three tasks in a dose-dependent manner; the extent of mobilization during the speech task correlated with concomitant cardiac activation, and was greater during higher intensity exercise and increased dose of beta-agonist infusion. The mobilization of gammadelta T lymphocytes was greater (in terms of % change from baseline) than that of CD8+ T lymphocytes and less than NK cells. This study is the first to demonstrate that gammadelta T cells are stress-responsive lymphocytes which are mobilised during psychological stress, exercise, and beta-agonist infusion. The mobilization of these versatile cytotoxic cells may provide protection in the context of situations in which antigen exposure is more likely to occur.

KW - Sympathetic reactivity

KW - Lymphocytosis

KW - Adaptive immunity

KW - T lymphocytes

KW - Infusion

KW - Exercise

KW - Acute stress

KW - Adrenergic

KW - Isoproterenol

KW - Innate immunity

U2 - 10.1016/j.bbi.2009.03.003

DO - 10.1016/j.bbi.2009.03.003

M3 - Article

C2 - 19318122

VL - 23

SP - 823

EP - 829

JO - Brain, Behaviour, and Immunity

JF - Brain, Behaviour, and Immunity

SN - 0889-1591

IS - 6

ER -