Mobile carrier ionophores for Fe(II)

Research output: Contribution to journalArticle

Authors

Colleges, School and Institutes

Abstract

A23187 and certain other carboxylate ionophores are capable of transferring Fe(II) but not Fe(III) across phospholipid bilayers (liposomes) and red cell membranes. A23187 is able to transfer Fe(II) from ferritin loaded liposomes when allied with a suitable redox couple and sink. The affinity of A23187 for Fe(II) is approximately five orders of magnitude greater than for Ca2+, as judged by two phase extraction techniques.

Details

Original languageEnglish
Pages (from-to)281-91
Number of pages11
JournalBiochimica et Biophysica Acta (BBA) - Biomembranes
Volume469
Issue number3
Publication statusPublished - 19 Sep 1977

Keywords

  • Humans, Lasalocid, Erythrocytes, Calcimycin, Cations, Divalent, Erythrocyte Membrane, Liposomes, Iron, Ionophores, Ferritins