Minimum Information about a Biosynthetic Gene cluster

Research output: Contribution to journalArticle

Authors

  • Marnix H. Medema
  • Renzo Kottmann
  • Pelin Yilmaz
  • Matthew Cummings
  • John B. Biggins
  • Kai Blin
  • Irene De Bruijn
  • Yit Heng Chooi
  • Jan Claesen
  • R. Cameron Coates
  • Pablo Cruz-Morales
  • Srikanth Duddela
  • Stephanie Düsterhus
  • Daniel J. Edwards
  • David P. Fewer
  • Neha Garg
  • Christoph Geiger
  • Juan Pablo Gomez-Escribano
  • Anja Greule
  • Michalis Hadjithomas
  • Eric J N Helfrich
  • Matthew L. Hillwig
  • Keishi Ishida
  • Adam C. Jones
  • Carla S. Jones
  • Katrin Jungmann
  • Carsten Kegler
  • Hyun Uk Kim
  • Peter Kötter
  • Daniel Krug
  • Joleen Masschelein
  • Alexey V. Melnik
  • Simone M. Mantovani
  • Emily A. Monroe
  • Marcus Moore
  • Nathan Moss
  • Hans Wilhelm Nützmann
  • Guohui Pan
  • Amrita Pati
  • Daniel Petras
  • F. Jerry Reen
  • Federico Rosconi
  • Zhe Rui
  • Zhenhua Tian
  • Nicholas J. Tobias
  • Yuta Tsunematsu
  • Philipp Wiemann
  • Elizabeth Wyckoff
  • Xiaohui Yan
  • Grace Yim
  • Fengan Yu
  • Yunchang Xie
  • Bertrand Aigle
  • Alexander K. Apel
  • Carl J. Balibar
  • Emily P. Balskus
  • Francisco Barona-Gómez
  • Andreas Bechthold
  • Helge B. Bode
  • Rainer Borriss
  • Sean F. Brady
  • Axel A. Brakhage
  • Patrick Caffrey
  • Yi Qiang Cheng
  • Jon Clardy
  • Russell J. Cox
  • René De Mot
  • Stefano Donadio
  • Mohamed S. Donia
  • Wilfred A. Van Der Donk
  • Pieter C. Dorrestein
  • Sean Doyle
  • Arnold J M Driessen
  • Monika Ehling-Schulz
  • Karl Dieter Entian
  • Michael A. Fischbach
  • Lena Gerwick
  • William H. Gerwick
  • Harald Gross
  • Bertolt Gust
  • Christian Hertweck
  • Monica Höfte
  • Susan E. Jensen
  • Jianhua Ju
  • Leonard Katz
  • Leonard Kaysser
  • Jonathan L. Klassen
  • Nancy P. Keller
  • Jan Kormanec
  • Oscar P. Kuipers
  • Tomohisa Kuzuyama
  • Nikos C. Kyrpides
  • Hyung Jin Kwon
  • Sylvie Lautru
  • Rob Lavigne
  • Chia Y. Lee
  • Bai Linquan
  • Xinyu Liu
  • Wen Liu
  • Andriy Luzhetskyy
  • Taifo Mahmud
  • Yvonne Mast
  • Carmen Méndez
  • Mikko Metsä-Ketelä
  • Jason Micklefield
  • Douglas A. Mitchell
  • Bradley S. Moore
  • Leonilde M. Moreira
  • Rolf Müller
  • Brett A. Neilan
  • Markus Nett
  • Jens Nielsen
  • Fergal O'Gara
  • Hideaki Oikawa
  • Anne Osbourn
  • Marcia S. Osburne
  • Bohdan Ostash
  • Shelley M. Payne
  • Jean Luc Pernodet
  • Miroslav Petricek
  • Jörn Piel
  • Olivier Ploux
  • Jos M. Raaijmakers
  • José A. Salas
  • Esther K. Schmitt
  • Barry Scott
  • Ryan F. Seipke
  • Ben Shen
  • David H. Sherman
  • Kaarina Sivonen
  • Michael J. Smanski
  • Margherita Sosio
  • Evi Stegmann
  • Roderich D. Süssmuth
  • Kapil Tahlan
  • Christopher M. Thomas
  • Yi Tang
  • Andrew W. Truman
  • Muriel Viaud
  • Jonathan D. Walton
  • Christopher T. Walsh
  • Tilmann Weber
  • Gilles P. Van Wezel
  • Barrie Wilkinson
  • Joanne M. Willey
  • Wolfgang Wohlleben
  • Gerard D. Wright
  • Nadine Ziemert
  • Changsheng Zhang
  • Sergey B. Zotchev
  • Rainer Breitling
  • Eriko Takano
  • Frank Oliver Glöckner

Colleges, School and Institutes

External organisations

  • University of California, San Francisco
  • Unité Mixte de Recherche 1309 Contrôle des Maladies Animales Exotiques et Emergentes, Institut national de la recherche agronomique (INRA)
  • University of California, San Diego
  • Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, United States of America; Howard Hughes Medical Institute, Albert Einstein College of Medicine, Bronx, New York, United States of America.
  • UNIVERSITY OF CALIFORNIA LOS ANGELES
  • Department of Geography, University of Wisconsin-Madison
  • Max Planck Institute for Marine Microbiology
  • University of Manchester
  • Faculty of Health and Life Sciences
  • Department of Microbial Ecology
  • Department of Chemical and Biomolecular Engineering
  • Department of Chemistry and Biochemistry, Queens College of CUNY, Flushing, NY 11367, USA.
  • School of Chemistry and Biochemistry, Georgia Institute of Technology
  • Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
  • BMT Unit, Department of Internal Medicine, University of Saarland, Saarbrucken, Germany.
  • Goethe University Frankfurt
  • University of Helsinki
  • 1] Department of Microbiology &Immunology, Peter Doherty Institute, University of Melbourne, Parkville, Australia. [2] Australian Research Council Centre of Excellence for Advanced Molecular Imaging, University of Melbourne, Australia.
  • Johann Wolfgang Goethe-Universität Frankfurt
  • Department of Biology, Universidad del Valle
  • Eduard-Zintl-Institut für Anorganische und Physikalische Chemie, Technische Universität Darmstadt, Petersenstrasse 20, 64287 Darmstadt, Germany. heiles@cluster.pc.chemie.tu-darmstadt.de
  • Technische Universität Berlin
  • Department of Microbiology and Immunology, Harvard Medical School, Boston, USA.
  • National University of Ireland
  • university of california, berkeley
  • Chinese Academy of Sciences
  • Infection and Immunity Unit; Institute for Molecular and Cellular Biology; University of Porto; Porto Portugal
  • Department of Biochemistry and Molecular Biology, School of Biomedical Sciences and Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, Victoria 3800, Australia.
  • Laboratory of Population & Quantitative Genetics, Institute of Genetics and Biostatistics, SKLG, School of Life Sciences, Fudan University, Shanghai, China.
  • Central Michigan University
  • Department of Chemistry and Medicinal Chemistry Programme, National University of Singapore, and Singapore Bioimaging Consortium, Agency for Science, Technology and Research (A(∗)STAR), Biopolis 117543, Singapore.
  • Department of Microbiology and Immunology, University of Tampere, Tampere, Finland.
  • Institute of Pharmaceutical Sciences
  • University of Tübingen
  • Humboldt-Universität zu Berlin
  • UCD School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Ireland.
  • Leibniz Universität Hannover, D-30167 Hannover, Germany
  • Department of Plant Production; Faculty of Bioscience Engineering; University of Ghent; Ghent 9000 Belgium
  • Division PMA (Production Engineering), University of Leuven (KU Leuven)
  • Department of Biochemistry and Molecular Biology, Faculty of Biology, Universitat de Barcelona, Barcelona, Spain.
  • Friedrich-Schiller University Jena, Germany
  • Ghent University
  • Department of Biological Sciences, University of Alberta
  • University of Aberdeen
  • Institute of Molecular Systems Biology
  • Institut de Physique Nucléaire, Université Paris-Sud-11-CNRS/IN2P3, , France
  • Department of Biochemistry
  • IN+, Instituto Superior Técnico, Universidade de Lisboa
  • Chalmers University of Technology
  • King's College London
  • Fuel Cells and Solid State Chemistry Division
  • Graduate School of Agricultural Science, Kobe University
  • Université Paris Diderot
  • Vrije Universiteit Amsterdam
  • School of Molecular and Cellular Biology
  • Faculty of Biological Sciences
  • Europ. Molecular Biology Laboratory
  • Department of Molecular Physiology and Biophysics
  • Institute of Systems Biotechnology
  • Leiden University
  • Department of Chemistry and Biotechnology
  • Norwegian University of Science and Technology
  • Microbial Genomics and Bioinformatics Research Group
  • Bioinformatics Group
  • Wageningen University and Research Centre
  • Manchester Centre for Synthetic Biology of Fine and Speciality Chemicals (SYNBIOCHEM)
  • Laboratory of Genetically Encoded Small Molecules
  • Rockefeller University
  • Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark
  • Netherlands Institute of Ecology
  • University of Western Australia
  • Department of Bioengineering and Therapeutic Sciences
  • California Institute for Quantitative Biosciences, University of California San Francisco
  • Department of Energy (DOE) Joint Genome Institute
  • Evolution of Metabolic Diversity Laboratory
  • Unidad de Genómica Avanzada (Langebio)
  • Centro de Investigacion y de Estudios Avanzados
  • Helmholtz Institute for Pharmaceutical Research
  • Department of Pharmaceutical Biotechnology
  • Institute for Molecular Biosciences
  • California State University Chico
  • Microbiology and Biotechnology Division
  • Department of Food and Environmental Sciences
  • Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego
  • John Innes Centre
  • Department of Pharmaceutical Biology and Biotechnology
  • Albert-Ludwigs-University of Freiburg
  • Eidgenössische Technische Hochschule (ETH) Zürich
  • University of Pittsburgh
  • Leibniz Institute for Natural Product Research and Infection Biology (HKI)
  • Gordon and Betty Moore Foundation
  • Sustainable Studies Program
  • Roosevelt University Chicago
  • Merck Stiftungsprofessur Für Molekulare Biotechnologie
  • Fachbereich Biowissenschaften
  • BioInformatics Research Center
  • Korea Advanced Institute of Science and Technology
  • Laboratory of Gene Technology, KU Leuven
  • Laboratory of Food Microbiology, KU Leuven
  • Center for Marine Biotechnology and Biomedicine
  • Scripps Institution of Oceanography
  • William Paterson University
  • Memorial University of Newfoundland
  • Department of Metabolic Biology
  • Scripps Research Institute
  • BIOMERIT Research Centre
  • University College Cork
  • Departamento de Bioquímica y Genómica Microbianas, IBCE
  • Energy Biosciences Institute
  • State Key Laboratory of Bioorganic and Natural Products Chemistry
  • Shanghai Institute of Organic Chemistry Chinese Academy of Sciences
  • Department of Pharmaceutical Sciences
  • University of Shizuoka
  • Department of Molecular Biosciences
  • University of Texas at Austin
  • M.G. DeGroote Institute for Infectious Disease Research
  • McMaster University
  • Key Laboratory of Tropical Marine Bio-resources and Ecology
  • Guangdong Key Laboratory of Marine Materia Medica
  • RNAM Center for Marine Microbiology
  • South China Sea Institute of Oceanology
  • Dynamique des Génomes et Adaptation Microbienne
  • Université de Lorraine and Institut National de la Recherche Agronomique (INRA)
  • Unité Mixte de Recherche (UMR) 1128
  • Department of Pharmaceutical Biology
  • German Centre for Infection Research (DZIF), Partner Site Tübingen
  • Infectious Disease Research
  • Merck Research Laboratories
  • Department of Chemistry and Chemical Biology
  • Harvard University
  • Buchmann Institute for Molecular Life Sciences (BMLS)
  • Fachbereich Phytomedizin
  • Albrecht Thaer Institut
  • UNT System College of Pharmacy
  • University of North Texas Health Science Center
  • Department of Biological Chemistry and Molecular Pharmacology
  • Harvard Medical School
  • Institut Für Organische Chemie
  • BRISTOL UNIVERSITY
  • Centre of Microbial and Plant Genetics
  • Naicons Srl
  • Princeton University
  • University of Illinois at Urbana-Champaign
  • Howard Hughes Medical Institute
  • Collaborative Mass Spectrometry Innovation Center
  • Maynooth University
  • Groningen Biomolecular Sciences and Biotechnology Institute
  • Zernike Institute for Advanced Materials
  • University of Groningen Biomolecular Sciences and Biotechnology Institute
  • Functional Microbiology
  • Department of Pathobiology
  • University of Veterinary Medicine Vienna
  • Department of Crop Protection
  • University of Alberta
  • Synthetic Biology Engineering Research Center (SynBERC)
  • University of California Emeryville
  • University of Connecticut
  • Department of Bacteriology
  • Slovak Academy of Sciences
  • Department of Molecular Genetics
  • Biotechnology Research Center
  • University of Tokyo
  • King Abdulaziz University
  • Division of Bioscience and Bioinformatics
  • Myongji University
  • Institute of Integrative Biology of the Cell (I2BC)
  • Commissariat À L'Energie Atomique (CEA)
  • Centre National de la Recherche Scientifique (CNRS)
  • University of Arkansas for Medical Sciences
  • State Key Laboratory of Microbial Metabolism
  • Shanghai Jiao Tong University
  • School of Life Sciences and Biotechnology, Shanghai Jiao Tong University
  • Oregon State University
  • Microbiology/Biotechnology
  • Interfaculty Institute of Microbiology and Infection Medicine
  • Departamento de Biología Funcional
  • Universidad de Oviedo
  • Instituto Universitario de Oncología Del Principado de Asturias (I.U.O.P.A), Universidad de Oviedo
  • University of Turku
  • Institute for Bioengineering and Biosciences
  • Universidade de Lisboa
  • School of Biotechnology and Biomolecular Sciences
  • University of New South Wales (UNSW) Australia
  • Department of Chemical and Biological Engineering
  • Curtin University
  • Hokkaido University
  • Department of Molecular Biology and Microbiology
  • Tufts University School of Medicine
  • Department of Genetics and Biotechnology
  • Ivan Franko National University of Lviv
  • Academy of Sciences of the Czech Republic (ASCR)
  • Institute of Microbiology of the Academy of Sciences of the Czech Republic
  • Laboratoire Interdisciplinaire des Energies de Demain (LIED)
  • UMR 8236 CNRS
  • Novartis
  • Massey University
  • Astbury Centre for Structural Molecular Biology
  • University of Leeds
  • Molecular Therapeutics and Natural Products Library Initiative
  • University of Minnesota-Twin Cities
  • Unité BIOlogie et GEstion des Risques en Agriculture (BIOGER)
  • Department of Energy Great Lakes Bioenergy Research Center
  • Department of Energy Plant Research Laboratory
  • Michigan State University
  • Engineering and Medicine for Human Health (ChEM-H) Institute
  • Stanford University
  • Molecular Biotechnology
  • Institute of Biology Leiden
  • Hofstra North Shore-Long Island Jewish School of Medicine
  • Jacobs University Bremen

Abstract

A wide variety of enzymatic pathways that produce specialized metabolites in bacteria, fungi and plants are known to be encoded in biosynthetic gene clusters. Information about these clusters, pathways and metabolites is currently dispersed throughout the literature, making it difficult to exploit. To facilitate consistent and systematic deposition and retrieval of data on biosynthetic gene clusters, we propose the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard.

Details

Original languageEnglish
Pages (from-to)625-631
Number of pages7
JournalNature Chemical Biology
Volume11
Issue number9
Publication statusPublished - 18 Aug 2015

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