Microstructural abnormalities in white and gray matter in obese adolescents with and without type 2 diabetes

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@article{9fefc00fb437469a905d14b24dcc1e77,
title = "Microstructural abnormalities in white and gray matter in obese adolescents with and without type 2 diabetes",
abstract = "AIMS/HYPOTHESES: In adults, type 2 diabetes and obesity have been associated with structural brain changes, even in the absence of dementia. Some evidence suggested similar changes in adolescents with type 2 diabetes but comparisons with a non-obese control group have been lacking. The aim of the current study was to examine differences in microstructure of gray and white matter between adolescents with type 2 diabetes, obese adolescents and healthy weight adolescents.METHODS: Magnetic resonance imaging data were collected from 15 adolescents with type 2 diabetes, 21 obese adolescents and 22 healthy weight controls. Volumetric differences in the gray matter between the three groups were examined using voxel based morphology, while tract based spatial statistics was used to examine differences in the microstructure of the white matter.RESULTS: Adolescents with type 2 diabetes and obese adolescents had reduced gray matter volume in the right hippocampus, left putamen and caudate, bilateral amygdala and left thalamus compared to healthy weight controls. Type 2 diabetes was also associated with significant regional changes in fractional anisotropy within the corpus callosum, fornix, left inferior fronto-occipital fasciculus, left uncinate, left internal and external capsule. Fractional anisotropy reductions within these tracts were explained by increased radial diffusivity, which may suggest demyelination of white matter tracts. Mean diffusivity and axial diffusivity did not differ between the groups.CONCLUSION/INTERPRETATION: Our data shows that adolescent obesity alone results in reduced gray matter volume and that adolescent type 2 diabetes is associated with both white and gray matter abnormalities.",
keywords = "Journal Article, type 2 diabetes , obesity , white matter , grey matter , demyelination",
author = "Arie Nouwen and Alison Chambers and Magdalena Chechlacz and Suzanne Higgs and Jacqueline Blissett and Barrett, {Timothy G} and Allen, {Harriet A}",
year = "2017",
doi = "10.1016/j.nicl.2017.07.004",
language = "English",
volume = "16",
pages = "43--51",
journal = "NeuroImage: Clinical",
issn = "2213-1582",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Microstructural abnormalities in white and gray matter in obese adolescents with and without type 2 diabetes

AU - Nouwen, Arie

AU - Chambers, Alison

AU - Chechlacz, Magdalena

AU - Higgs, Suzanne

AU - Blissett, Jacqueline

AU - Barrett, Timothy G

AU - Allen, Harriet A

PY - 2017

Y1 - 2017

N2 - AIMS/HYPOTHESES: In adults, type 2 diabetes and obesity have been associated with structural brain changes, even in the absence of dementia. Some evidence suggested similar changes in adolescents with type 2 diabetes but comparisons with a non-obese control group have been lacking. The aim of the current study was to examine differences in microstructure of gray and white matter between adolescents with type 2 diabetes, obese adolescents and healthy weight adolescents.METHODS: Magnetic resonance imaging data were collected from 15 adolescents with type 2 diabetes, 21 obese adolescents and 22 healthy weight controls. Volumetric differences in the gray matter between the three groups were examined using voxel based morphology, while tract based spatial statistics was used to examine differences in the microstructure of the white matter.RESULTS: Adolescents with type 2 diabetes and obese adolescents had reduced gray matter volume in the right hippocampus, left putamen and caudate, bilateral amygdala and left thalamus compared to healthy weight controls. Type 2 diabetes was also associated with significant regional changes in fractional anisotropy within the corpus callosum, fornix, left inferior fronto-occipital fasciculus, left uncinate, left internal and external capsule. Fractional anisotropy reductions within these tracts were explained by increased radial diffusivity, which may suggest demyelination of white matter tracts. Mean diffusivity and axial diffusivity did not differ between the groups.CONCLUSION/INTERPRETATION: Our data shows that adolescent obesity alone results in reduced gray matter volume and that adolescent type 2 diabetes is associated with both white and gray matter abnormalities.

AB - AIMS/HYPOTHESES: In adults, type 2 diabetes and obesity have been associated with structural brain changes, even in the absence of dementia. Some evidence suggested similar changes in adolescents with type 2 diabetes but comparisons with a non-obese control group have been lacking. The aim of the current study was to examine differences in microstructure of gray and white matter between adolescents with type 2 diabetes, obese adolescents and healthy weight adolescents.METHODS: Magnetic resonance imaging data were collected from 15 adolescents with type 2 diabetes, 21 obese adolescents and 22 healthy weight controls. Volumetric differences in the gray matter between the three groups were examined using voxel based morphology, while tract based spatial statistics was used to examine differences in the microstructure of the white matter.RESULTS: Adolescents with type 2 diabetes and obese adolescents had reduced gray matter volume in the right hippocampus, left putamen and caudate, bilateral amygdala and left thalamus compared to healthy weight controls. Type 2 diabetes was also associated with significant regional changes in fractional anisotropy within the corpus callosum, fornix, left inferior fronto-occipital fasciculus, left uncinate, left internal and external capsule. Fractional anisotropy reductions within these tracts were explained by increased radial diffusivity, which may suggest demyelination of white matter tracts. Mean diffusivity and axial diffusivity did not differ between the groups.CONCLUSION/INTERPRETATION: Our data shows that adolescent obesity alone results in reduced gray matter volume and that adolescent type 2 diabetes is associated with both white and gray matter abnormalities.

KW - Journal Article

KW - type 2 diabetes

KW - obesity

KW - white matter

KW - grey matter

KW - demyelination

U2 - 10.1016/j.nicl.2017.07.004

DO - 10.1016/j.nicl.2017.07.004

M3 - Article

C2 - 28752059

VL - 16

SP - 43

EP - 51

JO - NeuroImage: Clinical

JF - NeuroImage: Clinical

SN - 2213-1582

ER -