Microfluidic mass production of stabilized and stealthy liquid metal nanoparticles

Research output: Contribution to journalArticlepeer-review

Standard

Microfluidic mass production of stabilized and stealthy liquid metal nanoparticles. / Tang, Shi-Yang; Qiao, Ruirui; Yan, Sheng; Yuan, Dan; Zhao, Qianbin; Yun, Guolin; Davis, Thomas P.; Li, Weihua.

In: Small, Vol. 14, No. 21, 1800118, 22.05.2018.

Research output: Contribution to journalArticlepeer-review

Harvard

Tang, S-Y, Qiao, R, Yan, S, Yuan, D, Zhao, Q, Yun, G, Davis, TP & Li, W 2018, 'Microfluidic mass production of stabilized and stealthy liquid metal nanoparticles', Small, vol. 14, no. 21, 1800118. https://doi.org/10.1002/smll.201800118

APA

Tang, S-Y., Qiao, R., Yan, S., Yuan, D., Zhao, Q., Yun, G., Davis, T. P., & Li, W. (2018). Microfluidic mass production of stabilized and stealthy liquid metal nanoparticles. Small, 14(21), [1800118]. https://doi.org/10.1002/smll.201800118

Vancouver

Author

Tang, Shi-Yang ; Qiao, Ruirui ; Yan, Sheng ; Yuan, Dan ; Zhao, Qianbin ; Yun, Guolin ; Davis, Thomas P. ; Li, Weihua. / Microfluidic mass production of stabilized and stealthy liquid metal nanoparticles. In: Small. 2018 ; Vol. 14, No. 21.

Bibtex

@article{084677a95d394a819c2f9b1c59c6832a,
title = "Microfluidic mass production of stabilized and stealthy liquid metal nanoparticles",
abstract = "Functional nanoparticles comprised of liquid metals, such as eutectic gallium indium (EGaIn) and Galinstan, present exciting opportunities in the fields of flexible electronics, sensors, catalysts, and drug delivery systems. Methods used currently for producing liquid metal nanoparticles have significant disadvantages as they rely on both bulky and expensive high‐power sonication probe systems, and also generally require the use of small molecules bearing thiol groups to stabilize the nanoparticles. Herein, an innovative microfluidics‐enabled platform is described as an inexpensive, easily accessible method for the on‐chip mass production of EGaIn nanoparticles with tunable size distributions in an aqueous medium. A novel nanoparticle‐stabilization approach is reported using brushed polyethylene glycol chains with trithiocarbonate end‐groups negating the requirements for thiol additives while imparting a “stealth” surface layer. Furthermore, a surface modification of the nanoparticles is demonstrated using galvanic replacement and conjugation with antibodies. It is envisioned that the demonstrated microfluidic technique can be used as an economic and versatile platform for the rapid production of liquid metal‐based nanoparticles for a range of biomedical applications.",
keywords = "acoustics, EGaIn, liquid metals, microfluidics, nanoparticles",
author = "Shi-Yang Tang and Ruirui Qiao and Sheng Yan and Dan Yuan and Qianbin Zhao and Guolin Yun and Davis, {Thomas P.} and Weihua Li",
year = "2018",
month = may,
day = "22",
doi = "10.1002/smll.201800118",
language = "English",
volume = "14",
journal = "Small",
issn = "1613-6810",
publisher = "Wiley-VCH Verlag",
number = "21",

}

RIS

TY - JOUR

T1 - Microfluidic mass production of stabilized and stealthy liquid metal nanoparticles

AU - Tang, Shi-Yang

AU - Qiao, Ruirui

AU - Yan, Sheng

AU - Yuan, Dan

AU - Zhao, Qianbin

AU - Yun, Guolin

AU - Davis, Thomas P.

AU - Li, Weihua

PY - 2018/5/22

Y1 - 2018/5/22

N2 - Functional nanoparticles comprised of liquid metals, such as eutectic gallium indium (EGaIn) and Galinstan, present exciting opportunities in the fields of flexible electronics, sensors, catalysts, and drug delivery systems. Methods used currently for producing liquid metal nanoparticles have significant disadvantages as they rely on both bulky and expensive high‐power sonication probe systems, and also generally require the use of small molecules bearing thiol groups to stabilize the nanoparticles. Herein, an innovative microfluidics‐enabled platform is described as an inexpensive, easily accessible method for the on‐chip mass production of EGaIn nanoparticles with tunable size distributions in an aqueous medium. A novel nanoparticle‐stabilization approach is reported using brushed polyethylene glycol chains with trithiocarbonate end‐groups negating the requirements for thiol additives while imparting a “stealth” surface layer. Furthermore, a surface modification of the nanoparticles is demonstrated using galvanic replacement and conjugation with antibodies. It is envisioned that the demonstrated microfluidic technique can be used as an economic and versatile platform for the rapid production of liquid metal‐based nanoparticles for a range of biomedical applications.

AB - Functional nanoparticles comprised of liquid metals, such as eutectic gallium indium (EGaIn) and Galinstan, present exciting opportunities in the fields of flexible electronics, sensors, catalysts, and drug delivery systems. Methods used currently for producing liquid metal nanoparticles have significant disadvantages as they rely on both bulky and expensive high‐power sonication probe systems, and also generally require the use of small molecules bearing thiol groups to stabilize the nanoparticles. Herein, an innovative microfluidics‐enabled platform is described as an inexpensive, easily accessible method for the on‐chip mass production of EGaIn nanoparticles with tunable size distributions in an aqueous medium. A novel nanoparticle‐stabilization approach is reported using brushed polyethylene glycol chains with trithiocarbonate end‐groups negating the requirements for thiol additives while imparting a “stealth” surface layer. Furthermore, a surface modification of the nanoparticles is demonstrated using galvanic replacement and conjugation with antibodies. It is envisioned that the demonstrated microfluidic technique can be used as an economic and versatile platform for the rapid production of liquid metal‐based nanoparticles for a range of biomedical applications.

KW - acoustics

KW - EGaIn

KW - liquid metals

KW - microfluidics

KW - nanoparticles

UR - https://doi.org/10.1002/smll.201800118

U2 - 10.1002/smll.201800118

DO - 10.1002/smll.201800118

M3 - Article

VL - 14

JO - Small

JF - Small

SN - 1613-6810

IS - 21

M1 - 1800118

ER -