Microenvironmental regulation of Notch signalling in T-cell development

Research output: Contribution to journalArticle

Colleges, School and Institutes

Abstract

T cells develop in the thymus from blood-borne progenitors derived from haematopoietic tissues. Amongst the mechanisms by which stromal cells in thymic and prethymic tissues influence lymphoid progenitors, recent attention has focussed on the importance of Notch signalling in early T cell development. Here, we review evidence that developing T cells and their progenitors receive signals through Notch receptors as a result of interactions with Notch ligands expressed by stromal cells. In particular, we focus on the role of Notch ligand-expressing stromal cells in regulating key control points during pre- and intrathymic phases of T cell development.

Details

Original languageEnglish
Pages (from-to)91-97
Number of pages7
JournalSeminars in Immunology
Volume15
Issue number2
Publication statusPublished - 1 Apr 2003

Keywords

  • Notch, T cell development, lymphoid progenitor, microenvironment