TY - JOUR
T1 - Microbial influences on epithelial integrity and immune function as a basis for inflammatory diseases
AU - Macia, Laurence
AU - Thorburn, Alison N.
AU - Binge, Lauren C.
AU - Marino, Eliana
AU - Rogers, Kate E.
AU - Maslowski, Kendle M.
AU - Vieira, Angélica T.
AU - Kranich, Jan
AU - Mackay, Charles R.
PY - 2012/1
Y1 - 2012/1
N2 - Certain autoimmune diseases as well as asthma have increased in recent decades, particularly in developed countries. The hygiene hypothesis has been the prevailing model to account for this increase; however, epidemiology studies also support the contribution of diet and obesity to inflammatory diseases. Diet affects the composition of the gut microbiota, and recent studies have identified various molecules and mechanisms that connect diet, the gut microbiota, and immune responses. Herein, we discuss the effects of microbial metabolites, such as short chain fatty acids, on epithelial integrity as well as immune cell function. We propose that dysbiosis contributes to compromised epithelial integrity and disrupted immune tolerance. In addition, dietary molecules affect the function of immune cells directly, particularly through lipid G-protein coupled receptors such as GPR43.
AB - Certain autoimmune diseases as well as asthma have increased in recent decades, particularly in developed countries. The hygiene hypothesis has been the prevailing model to account for this increase; however, epidemiology studies also support the contribution of diet and obesity to inflammatory diseases. Diet affects the composition of the gut microbiota, and recent studies have identified various molecules and mechanisms that connect diet, the gut microbiota, and immune responses. Herein, we discuss the effects of microbial metabolites, such as short chain fatty acids, on epithelial integrity as well as immune cell function. We propose that dysbiosis contributes to compromised epithelial integrity and disrupted immune tolerance. In addition, dietary molecules affect the function of immune cells directly, particularly through lipid G-protein coupled receptors such as GPR43.
KW - Epithelium
KW - GPR43
KW - Microbiota
KW - Short-chain fatty acids
UR - http://www.scopus.com/inward/record.url?scp=83655193494&partnerID=8YFLogxK
U2 - 10.1111/j.1600-065X.2011.01080.x
DO - 10.1111/j.1600-065X.2011.01080.x
M3 - Review article
C2 - 22168419
AN - SCOPUS:83655193494
SN - 0105-2896
VL - 245
SP - 164
EP - 176
JO - Immunological Reviews
JF - Immunological Reviews
IS - 1
ER -