Metal-organic frameworks for the storage and delivery of biologically active hydrogen sulfide

PK Allan; PS Wheatley; D Aldous; MI Mohideen; C Tang; Joseph Hriljac; IL Megson; KW Chapman; G De Weireld; S Vaesen; RE Morris

doi:10.1039/c2dt12069k

Metal-organic frameworks for the storage and delivery of biologically active hydrogen sulfide

PK Allan, PS Wheatley, D Aldous, MI Mohideen, C Tang, Joseph Hriljac, IL Megson, KW Chapman, G De Weireld, S Vaesen, RE Morris

Chemistry

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101 Citations (Scopus)

Abstract

Hydrogen sulfide is an extremely toxic gas that is also of great interest for biological applications when delivered in the correct amount and at the desired rate. Here we show that the highly porous metal-organic frameworks with the CPO-27 structure can bind the hydrogen sulfide relatively strongly, allowing the storage of the gas for at least several months. Delivered gas is biologically active in preliminary vasodilation studies of porcine arteries, and the structure of the hydrogen sulfide molecules inside the framework has been elucidated using a combination of powder X-ray diffraction and pair distribution function analysis.

Original language	English
Pages (from-to)	4060-4066
Number of pages	7
Journal	Dalton Transactions
Volume	41
Issue number	14
DOIs	https://doi.org/10.1039/c2dt12069k
Publication status	Published - 1 Jan 2012

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abstract = "Hydrogen sulfide is an extremely toxic gas that is also of great interest for biological applications when delivered in the correct amount and at the desired rate. Here we show that the highly porous metal-organic frameworks with the CPO-27 structure can bind the hydrogen sulfide relatively strongly, allowing the storage of the gas for at least several months. Delivered gas is biologically active in preliminary vasodilation studies of porcine arteries, and the structure of the hydrogen sulfide molecules inside the framework has been elucidated using a combination of powder X-ray diffraction and pair distribution function analysis.",

author = "PK Allan and PS Wheatley and D Aldous and MI Mohideen and C Tang and Joseph Hriljac and IL Megson and KW Chapman and {De Weireld}, G and S Vaesen and RE Morris",

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AU - Allan, PK

AU - Wheatley, PS

AU - Aldous, D

AU - Mohideen, MI

AU - Tang, C

AU - Hriljac, Joseph

AU - Megson, IL

AU - Chapman, KW

AU - De Weireld, G

AU - Vaesen, S

AU - Morris, RE

PY - 2012/1/1

Y1 - 2012/1/1

N2 - Hydrogen sulfide is an extremely toxic gas that is also of great interest for biological applications when delivered in the correct amount and at the desired rate. Here we show that the highly porous metal-organic frameworks with the CPO-27 structure can bind the hydrogen sulfide relatively strongly, allowing the storage of the gas for at least several months. Delivered gas is biologically active in preliminary vasodilation studies of porcine arteries, and the structure of the hydrogen sulfide molecules inside the framework has been elucidated using a combination of powder X-ray diffraction and pair distribution function analysis.

AB - Hydrogen sulfide is an extremely toxic gas that is also of great interest for biological applications when delivered in the correct amount and at the desired rate. Here we show that the highly porous metal-organic frameworks with the CPO-27 structure can bind the hydrogen sulfide relatively strongly, allowing the storage of the gas for at least several months. Delivered gas is biologically active in preliminary vasodilation studies of porcine arteries, and the structure of the hydrogen sulfide molecules inside the framework has been elucidated using a combination of powder X-ray diffraction and pair distribution function analysis.

U2 - 10.1039/c2dt12069k

DO - 10.1039/c2dt12069k

M3 - Article

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SN - 1477-9234

VL - 41

SP - 4060

EP - 4066

JO - Dalton Transactions

JF - Dalton Transactions

IS - 14

ER -

Metal-organic frameworks for the storage and delivery of biologically active hydrogen sulfide

Abstract

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