Metalloproteinases in idiopathic pulmonary fibrosis.

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Colleges, School and Institutes


In this review, we outline the current state of knowledge about the balance between collagen production and degradation in idiopathic pulmonary fibrosis (IPF). The dysregulated action of metalloproteinases implicated in IPF may play a central role in the disease pathogenesis. Inhibiting metalloproteinases in IPF may therefore have therapeutic potential but our knowledge of their pathophysiological role is held back by limited animal models and the lack of specific inhibitors.


Original languageEnglish
JournalThe European respiratory journal
Publication statusPublished - 23 Jun 2011