Metallo supramolecular cylinders inhibit HIV-1 TAR-TAT complex formation and viral replication in cellulo
Research output: Contribution to journal › Article › peer-review
- School of Chemistry, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK. firstname.lastname@example.org.
- Institute of Immunology and Immunotherapy Centre for Human Virology, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
- Nuffield Department of Medicine, Oxford University, Oxford, OX3 7BN, UK. email@example.com.
- School of Chemistry, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK. firstname.lastname@example.org.
Shape-selective recognition of nucleic acid structures by supramolecular drugs offers the potential to treat disease. The Trans Activation Response (TAR) region is a region of high secondary structure within the human immunodeficiency virus-1 (HIV-1) RNA that complexes with the virus-encoded Transactivator protein (TAT) and regulates viral transcription. Herein, we explore different metallo-supramolecular triple stranded helicates (cylinders) that target the TAR bulge motif and inhibit the formation of TAR-TAT complexes and HIV infection. Cylinders that incorporate Ni(II) and Ru(II) showed the most potent anti-viral activity with limited evidence of cellular cytotoxicity. These metallo-supramolecular compounds provide an exciting avenue for developing a new class of anti-viral agents.
|Publication status||Published - 6 Sep 2018|