Metabolomics to identify biomarkers and as a predictive tool in inflammatory diseases

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@article{590866b57e794983bed05ff80376914d,
title = "Metabolomics to identify biomarkers and as a predictive tool in inflammatory diseases",
abstract = "There is an overwhelming need for a simple, reliable tool that aids clinicians in diagnosing, assessing disease activity and treating rheumatic conditions. Identification of biomarkers in partially understood inflammatory disorders has long been sought after as the Holy Grail of Rheumatology. Given the complex nature of inflammatory conditions, it has been difficult to earmark the potentialbiomarkers. Metabolomics, however, is promising in providing new insights into inflammatory conditions and also identifying such biomarkers. Metabolomic studies have generally revealed increased energy requirements for by-products of a hypoxic environment, leading to a characteristic metabolic fingerprint. Here, we discuss the significance of such studies and their potential as a biomarker.",
author = "Gurpreet Jutley and Stephen Young",
year = "2015",
month = dec
doi = "10.1016/j.berh.2016.02.010",
language = "English",
volume = "29",
pages = "770--782",
journal = "Best Practice & Research: Clinical Rheumatology",
issn = "1521-6942",
publisher = "Elsevier",
number = "6",

}

RIS

TY - JOUR

T1 - Metabolomics to identify biomarkers and as a predictive tool in inflammatory diseases

AU - Jutley, Gurpreet

AU - Young, Stephen

PY - 2015/12

Y1 - 2015/12

N2 - There is an overwhelming need for a simple, reliable tool that aids clinicians in diagnosing, assessing disease activity and treating rheumatic conditions. Identification of biomarkers in partially understood inflammatory disorders has long been sought after as the Holy Grail of Rheumatology. Given the complex nature of inflammatory conditions, it has been difficult to earmark the potentialbiomarkers. Metabolomics, however, is promising in providing new insights into inflammatory conditions and also identifying such biomarkers. Metabolomic studies have generally revealed increased energy requirements for by-products of a hypoxic environment, leading to a characteristic metabolic fingerprint. Here, we discuss the significance of such studies and their potential as a biomarker.

AB - There is an overwhelming need for a simple, reliable tool that aids clinicians in diagnosing, assessing disease activity and treating rheumatic conditions. Identification of biomarkers in partially understood inflammatory disorders has long been sought after as the Holy Grail of Rheumatology. Given the complex nature of inflammatory conditions, it has been difficult to earmark the potentialbiomarkers. Metabolomics, however, is promising in providing new insights into inflammatory conditions and also identifying such biomarkers. Metabolomic studies have generally revealed increased energy requirements for by-products of a hypoxic environment, leading to a characteristic metabolic fingerprint. Here, we discuss the significance of such studies and their potential as a biomarker.

U2 - 10.1016/j.berh.2016.02.010

DO - 10.1016/j.berh.2016.02.010

M3 - Article

VL - 29

SP - 770

EP - 782

JO - Best Practice & Research: Clinical Rheumatology

JF - Best Practice & Research: Clinical Rheumatology

SN - 1521-6942

IS - 6

ER -