Metabolomics to identify biomarkers and as a predictive tool in inflammatory diseases

Research output: Contribution to journalArticle

Colleges, School and Institutes

Abstract

There is an overwhelming need for a simple, reliable tool that aids clinicians in diagnosing, assessing disease activity and treating rheumatic conditions. Identification of biomarkers in partially understood inflammatory disorders has long been sought after as the Holy Grail of Rheumatology. Given the complex nature of inflammatory conditions, it has been difficult to earmark the potential
biomarkers. Metabolomics, however, is promising in providing new insights into inflammatory conditions and also identifying such biomarkers. Metabolomic studies have generally revealed increased energy requirements for by-products of a hypoxic environment, leading to a characteristic metabolic fingerprint. Here, we discuss the significance of such studies and their potential as a biomarker.

Details

Original languageEnglish
Pages (from-to)770-782
JournalBest Practice and Research: Clinical Rheumatology
Volume29
Issue number6
Publication statusPublished - Dec 2015