Metabolomics enables precision medicine: “A White Paper, Community Perspective”

Research output: Contribution to journalArticlepeer-review

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Metabolomics enables precision medicine: “A White Paper, Community Perspective”. / Beger, Richard D.; Dunn, Warwick; Schmidt, Michael A.; Gross, Steven S.; Kirwan, Jennifer A.; Cascante, Marta; Brennan, Lorraine; Wishart, David S.; Oresic, Matej; Hankemeier, Thomas; Broadhurst, David I.; Lane, Andrew N.; Suhre, Karsten; Kastenmüller, Gabi; Sumner, Susan J.; Thiele, Ines; Fiehn, Oliver; Kaddurah-daouk, Rima.

In: Metabolomics, Vol. 12, No. 10, 149, 01.10.2016.

Research output: Contribution to journalArticlepeer-review

Harvard

Beger, RD, Dunn, W, Schmidt, MA, Gross, SS, Kirwan, JA, Cascante, M, Brennan, L, Wishart, DS, Oresic, M, Hankemeier, T, Broadhurst, DI, Lane, AN, Suhre, K, Kastenmüller, G, Sumner, SJ, Thiele, I, Fiehn, O & Kaddurah-daouk, R 2016, 'Metabolomics enables precision medicine: “A White Paper, Community Perspective”', Metabolomics, vol. 12, no. 10, 149. https://doi.org/10.1007/s11306-016-1094-6

APA

Beger, R. D., Dunn, W., Schmidt, M. A., Gross, S. S., Kirwan, J. A., Cascante, M., Brennan, L., Wishart, D. S., Oresic, M., Hankemeier, T., Broadhurst, D. I., Lane, A. N., Suhre, K., Kastenmüller, G., Sumner, S. J., Thiele, I., Fiehn, O., & Kaddurah-daouk, R. (2016). Metabolomics enables precision medicine: “A White Paper, Community Perspective”. Metabolomics, 12(10), [149]. https://doi.org/10.1007/s11306-016-1094-6

Vancouver

Author

Beger, Richard D. ; Dunn, Warwick ; Schmidt, Michael A. ; Gross, Steven S. ; Kirwan, Jennifer A. ; Cascante, Marta ; Brennan, Lorraine ; Wishart, David S. ; Oresic, Matej ; Hankemeier, Thomas ; Broadhurst, David I. ; Lane, Andrew N. ; Suhre, Karsten ; Kastenmüller, Gabi ; Sumner, Susan J. ; Thiele, Ines ; Fiehn, Oliver ; Kaddurah-daouk, Rima. / Metabolomics enables precision medicine: “A White Paper, Community Perspective”. In: Metabolomics. 2016 ; Vol. 12, No. 10.

Bibtex

@article{4b00037e3cec41cea5f4b2efe2436beb,
title = "Metabolomics enables precision medicine: “A White Paper, Community Perspective”",
abstract = "Metabolomics is the comprehensive study of the metabolome, the repertoire of biochemicals (or small molecules) present in cells, tissues, and body fluids. The study of metabolism at the global or “-omics” level is a rapidly growing field that has the potential to have a profound impact upon medical practice. At the center of metabolomics, is the concept that a person{\textquoteright}s metabolic state provides a close representation of that individual{\textquoteright}s overall health status. This metabolic state reflects what has been encoded by the genome, and modified by diet, environmental factors, and the gut microbiome. The metabolic profile provides a quantifiable readout of biochemical state from normal physiology to diverse pathophysiologies in a manner that is often not obvious from gene expression analyses. Today, clinicians capture only a very small part of the information contained in the metabolome, as they routinely measure only a narrow set of blood chemistry analytes to assess health and disease states. Examples include measuring glucose to monitor diabetes, measuring cholesterol and high density lipoprotein/low density lipoprotein ratio to assess cardiovascular health, BUN and creatinine for renal disorders, and measuring a panel of metabolites to diagnose potential inborn errors of metabolism in neonates.",
keywords = "Metabolomics, Metabonomics, Pharmacometabolomics, Pharmacometabonomics, Precision medicine, Personalized medicine",
author = "Beger, {Richard D.} and Warwick Dunn and Schmidt, {Michael A.} and Gross, {Steven S.} and Kirwan, {Jennifer A.} and Marta Cascante and Lorraine Brennan and Wishart, {David S.} and Matej Oresic and Thomas Hankemeier and Broadhurst, {David I.} and Lane, {Andrew N.} and Karsten Suhre and Gabi Kastenm{\"u}ller and Sumner, {Susan J.} and Ines Thiele and Oliver Fiehn and Rima Kaddurah-daouk",
year = "2016",
month = oct,
day = "1",
doi = "10.1007/s11306-016-1094-6",
language = "English",
volume = "12",
journal = "Metabolomics",
issn = "1573-3882",
publisher = "Springer",
number = "10",

}

RIS

TY - JOUR

T1 - Metabolomics enables precision medicine: “A White Paper, Community Perspective”

AU - Beger, Richard D.

AU - Dunn, Warwick

AU - Schmidt, Michael A.

AU - Gross, Steven S.

AU - Kirwan, Jennifer A.

AU - Cascante, Marta

AU - Brennan, Lorraine

AU - Wishart, David S.

AU - Oresic, Matej

AU - Hankemeier, Thomas

AU - Broadhurst, David I.

AU - Lane, Andrew N.

AU - Suhre, Karsten

AU - Kastenmüller, Gabi

AU - Sumner, Susan J.

AU - Thiele, Ines

AU - Fiehn, Oliver

AU - Kaddurah-daouk, Rima

PY - 2016/10/1

Y1 - 2016/10/1

N2 - Metabolomics is the comprehensive study of the metabolome, the repertoire of biochemicals (or small molecules) present in cells, tissues, and body fluids. The study of metabolism at the global or “-omics” level is a rapidly growing field that has the potential to have a profound impact upon medical practice. At the center of metabolomics, is the concept that a person’s metabolic state provides a close representation of that individual’s overall health status. This metabolic state reflects what has been encoded by the genome, and modified by diet, environmental factors, and the gut microbiome. The metabolic profile provides a quantifiable readout of biochemical state from normal physiology to diverse pathophysiologies in a manner that is often not obvious from gene expression analyses. Today, clinicians capture only a very small part of the information contained in the metabolome, as they routinely measure only a narrow set of blood chemistry analytes to assess health and disease states. Examples include measuring glucose to monitor diabetes, measuring cholesterol and high density lipoprotein/low density lipoprotein ratio to assess cardiovascular health, BUN and creatinine for renal disorders, and measuring a panel of metabolites to diagnose potential inborn errors of metabolism in neonates.

AB - Metabolomics is the comprehensive study of the metabolome, the repertoire of biochemicals (or small molecules) present in cells, tissues, and body fluids. The study of metabolism at the global or “-omics” level is a rapidly growing field that has the potential to have a profound impact upon medical practice. At the center of metabolomics, is the concept that a person’s metabolic state provides a close representation of that individual’s overall health status. This metabolic state reflects what has been encoded by the genome, and modified by diet, environmental factors, and the gut microbiome. The metabolic profile provides a quantifiable readout of biochemical state from normal physiology to diverse pathophysiologies in a manner that is often not obvious from gene expression analyses. Today, clinicians capture only a very small part of the information contained in the metabolome, as they routinely measure only a narrow set of blood chemistry analytes to assess health and disease states. Examples include measuring glucose to monitor diabetes, measuring cholesterol and high density lipoprotein/low density lipoprotein ratio to assess cardiovascular health, BUN and creatinine for renal disorders, and measuring a panel of metabolites to diagnose potential inborn errors of metabolism in neonates.

KW - Metabolomics

KW - Metabonomics

KW - Pharmacometabolomics

KW - Pharmacometabonomics

KW - Precision medicine

KW - Personalized medicine

U2 - 10.1007/s11306-016-1094-6

DO - 10.1007/s11306-016-1094-6

M3 - Article

VL - 12

JO - Metabolomics

JF - Metabolomics

SN - 1573-3882

IS - 10

M1 - 149

ER -