Metabolism inspired electrosynthesis

Research output: Contribution to journalReview article

Authors

Colleges, School and Institutes

Abstract

Drug metabolism is a critical stage in the development of new chemical entities to understand how the drug will behave in the body and to reveal potential toxic metabolites. In this Review, we discuss how a renaissance in the applications of synthetic electrochemistry can be employed both to identify drug metabolites (and mechanisms) and enable electrosynthetic preparation of drug metabolites for further analysis. Recent advances in electro‐oxidative drug reactions are reviewed together with a perspective on the future use of electrosynthesis to diversify lead stage drug molecules to enable rapid testing of advanced analogues. A focus on the remarkable advances in the last decade with the inclusion of seminal papers for contextual analysis are reviewed.

Details

Original languageEnglish
Pages (from-to)4093-4104
Number of pages12
JournalChemElectroChem
Volume6
Issue number16
Early online date25 Feb 2019
Publication statusPublished - 16 Aug 2019

Keywords

  • electrosynthesis, diversification, metabolism, oxidation, drugs