Metabolism inspired electrosynthesis
Research output: Contribution to journal › Review article
Colleges, School and Institutes
Drug metabolism is a critical stage in the development of new chemical entities to understand how the drug will behave in the body and to reveal potential toxic metabolites. In this Review, we discuss how a renaissance in the applications of synthetic electrochemistry can be employed both to identify drug metabolites (and mechanisms) and enable electrosynthetic preparation of drug metabolites for further analysis. Recent advances in electro‐oxidative drug reactions are reviewed together with a perspective on the future use of electrosynthesis to diversify lead stage drug molecules to enable rapid testing of advanced analogues. A focus on the remarkable advances in the last decade with the inclusion of seminal papers for contextual analysis are reviewed.
|Number of pages||12|
|Early online date||25 Feb 2019|
|Publication status||Published - 16 Aug 2019|
- electrosynthesis, diversification, metabolism, oxidation, drugs