Metabolism at the centre of the host-microbe relationship
Research output: Contribution to journal › Review article › peer-review
Colleges, School and Institutes
- Institute of Immunology and Immunotherapy and Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK.
Maintaining homoeostatic host-microbe interactions is vital for host immune function. The gut microbiota shapes the host immune system and the immune system reciprocally shapes and modifies the gut microbiota. However, our understanding of how these microbes are tolerated and how individual, or communities of, gut microbes influence host function is limited. This review will focus on metabolites as key mediators of this complex host-microbe relationship. It will look at the central role of epithelial metabolism in shaping the gut microbiota, how microbial metabolites influence the epithelium and the mucosal and peripheral immune system, and how the immune system shapes microbial composition and metabolism. Finally, this review will look at how metabolites are involved in cross-talk between different members of the microbiota and their role during infections.
|Number of pages||12|
|Journal||Clinical and Experimental Immunology|
|Early online date||20 May 2019|
|Publication status||Published - Aug 2019|
- autoimmunity, dysbiosis, host-pathogen interactions, infection, inflammation, physiological hypoxia