Metabolic syndrome and lung function in schizophrenia: a pilot study

Research output: Contribution to journalArticle

Authors

  • Davy Vancampfort
  • Michel Probst
  • Brendon Stubbs
  • Amber De Herdt
  • Marc De Hert

Colleges, School and Institutes

Abstract

This pilot study aimed to explore relationships between metabolic and lung functions in patients with schizophrenia. Eighty patients with schizophrenia (55♂; 36.8±10.0 years) underwent a spirometry, were screened for metabolic syndrome (MetS), performed a 6-min walk test (6MWT), and completed the International Physical Activity Questionnaire and the Psychosis evaluation tool for common use by caregivers. Patients with MetS (according to the International Diabetes Federation criteria) (n=28; 35%) had a reduced predicted forced expiratory volume for 1 second (77.4±13.2% versus 87.3±12.1%) and predicted forced vital capacity (75.3±11.1% versus 85.4±11.4%). Significantly more patients with MetS were diagnosed with restrictive lung dysfunction (RLD) (according to the Global Initiative for Chronic Obstructive Lung Disease criteria) (13 versus 8). Schizophrenia patients with RLD (n=21; 26.2%) had a significantly larger waist circumference (90.7±12.5 versus 105.6±14.7 cm), were less physically active (653.6±777.9 versus 1517.9±1248.7 metabolic equivalent min/week) and walked less on the 6MWT (502.6±92.3 versus 612.4±101.2 m) than patients without RLD. The present data suggest that in patients with schizophrenia RLD might be associated with metabolic dysfunctions. Further prospective analyses are required to elucidate the complex interrelationships between lung and metabolic functions in patients with schizophrenia.

Details

Original languageEnglish
Pages (from-to)58-62
Number of pages5
JournalPsychiatry Research
Volume220
Issue number1-2
Early online date12 Jun 2014
Publication statusPublished - 15 Dec 2014

Keywords

  • Spirometry, Metabolic syndrome, Physical activity, Exercise, Physical fitness, Psychosis