Metabolic Modulator Perhexiline Corrects Energy Deficiency and Improves Exercise Capacity in Symptomatic Hypertrophic Cardiomyopathy

Research output: Contribution to journalArticle

Authors

  • P Elliott
  • W McKenna
  • TT Phan
  • Ganesh Nallur Shivu
  • K Kaur
  • J Taylor
  • A Henning
  • H Ashrafian
  • H Watkins
  • M Frenneaux

Colleges, School and Institutes

Abstract

Background-Hypertrophic cardiomyopathy patients exhibit myocardial energetic impairment, but a causative role for this energy deficiency in the pathophysiology of hypertrophic cardiomyopathy remains unproven. We hypothesized that the metabolic modulator perhexiline would ameliorate myocardial energy deficiency and thereby improve diastolic function and exercise capacity. Methods and Results-Forty-six consecutive patients with symptomatic exercise limitation (peak (V)over doto(2)

Details

Original languageEnglish
Pages (from-to)1562-U56
JournalCirculation
Volume122
Issue number16
Publication statusPublished - 1 Oct 2010

Keywords

  • hypertrophy, metabolism, exercise, cardiomyopathy, spectroscopy