Metabolic footprinting and systems biology: the medium is the message

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Metabolic footprinting and systems biology : the medium is the message. / Kell, Douglas B; Brown, Marie; Davey, Hazel M; Dunn, Warwick B; Spasic, Irena; Oliver, Stephen G.

In: Nature Reviews Microbiology, Vol. 3, No. 7, 07.2005, p. 557-65.

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Kell, Douglas B ; Brown, Marie ; Davey, Hazel M ; Dunn, Warwick B ; Spasic, Irena ; Oliver, Stephen G. / Metabolic footprinting and systems biology : the medium is the message. In: Nature Reviews Microbiology. 2005 ; Vol. 3, No. 7. pp. 557-65.

Bibtex

@article{89b77b1a58f146b59e3b0e70c61310b8,
title = "Metabolic footprinting and systems biology: the medium is the message",
abstract = "One element of classical systems analysis treats a system as a black or grey box, the inner structure and behaviour of which can be analysed and modelled by varying an internal or external condition, probing it from outside and studying the effect of the variation on the external observables. The result is an understanding of the inner make-up and workings of the system. The equivalent of this in biology is to observe what a cell or system excretes under controlled conditions - the 'metabolic footprint' or exometabolome - as this is readily and accurately measurable. Here, we review the principles, experimental approaches and scientific outcomes that have been obtained with this useful and convenient strategy.",
author = "Kell, {Douglas B} and Marie Brown and Davey, {Hazel M} and Dunn, {Warwick B} and Irena Spasic and Oliver, {Stephen G}",
year = "2005",
month = jul,
doi = "10.1038/nrmicro1177",
language = "English",
volume = "3",
pages = "557--65",
journal = "Nature Reviews Microbiology",
issn = "1740-1526",
publisher = "Nature Publishing Group",
number = "7",

}

RIS

TY - JOUR

T1 - Metabolic footprinting and systems biology

T2 - the medium is the message

AU - Kell, Douglas B

AU - Brown, Marie

AU - Davey, Hazel M

AU - Dunn, Warwick B

AU - Spasic, Irena

AU - Oliver, Stephen G

PY - 2005/7

Y1 - 2005/7

N2 - One element of classical systems analysis treats a system as a black or grey box, the inner structure and behaviour of which can be analysed and modelled by varying an internal or external condition, probing it from outside and studying the effect of the variation on the external observables. The result is an understanding of the inner make-up and workings of the system. The equivalent of this in biology is to observe what a cell or system excretes under controlled conditions - the 'metabolic footprint' or exometabolome - as this is readily and accurately measurable. Here, we review the principles, experimental approaches and scientific outcomes that have been obtained with this useful and convenient strategy.

AB - One element of classical systems analysis treats a system as a black or grey box, the inner structure and behaviour of which can be analysed and modelled by varying an internal or external condition, probing it from outside and studying the effect of the variation on the external observables. The result is an understanding of the inner make-up and workings of the system. The equivalent of this in biology is to observe what a cell or system excretes under controlled conditions - the 'metabolic footprint' or exometabolome - as this is readily and accurately measurable. Here, we review the principles, experimental approaches and scientific outcomes that have been obtained with this useful and convenient strategy.

U2 - 10.1038/nrmicro1177

DO - 10.1038/nrmicro1177

M3 - Article

C2 - 15953932

VL - 3

SP - 557

EP - 565

JO - Nature Reviews Microbiology

JF - Nature Reviews Microbiology

SN - 1740-1526

IS - 7

ER -