Metabolic Concepts in Idiopathic Intracranial Hypertension and Their Potential for Therapeutic Intervention

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Metabolic Concepts in Idiopathic Intracranial Hypertension and Their Potential for Therapeutic Intervention. / Hornby, Catherine; Mollan, Susan; Botfield, Hannah; OʼReilly, Michael W.; Sinclair, Alexandra.

In: Journal of Neuro-Ophthalmology, Vol. 38, No. 4, 12.2018, p. 522–530.

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@article{6c65bad24830405ba1204c8b51c26784,
title = "Metabolic Concepts in Idiopathic Intracranial Hypertension and Their Potential for Therapeutic Intervention",
abstract = "BACKGROUND: Traditional risk factors associated with idiopathic intracranial hypertension (IIH) include obesity, weight gain, and female sex. The incidence of IIH is increasing and yet the underlying trigger and the fueling pathological mechanisms are still poorly understood.EVIDENCE ACQUISITION: Review of ophthalmology, neurology, general surgery, obesity, endocrinology, nutrition, and neurosurgery literature was made.RESULTS: The facts that implicate sex and obesity in IIH and headache are examined. The role of fat distribution in IIH is questioned, and the concept of adipose tissue functioning as an endocrine organ driving IIH is discussed. The impact of androgen metabolism in IIH is reviewed as is the emerging role of glucagon-like-peptide-1 analogues in modulating intracranial pressure. This introduces the concept of developing targeted disease-modifying therapeutic strategies for IIH.CONCLUSIONS: This review will discuss the possible role of the adipose/gut/brain metabolism axis in IIH and speculate how this may impact the pathogenesis of IIH and therapeutic opportunities.",
author = "Catherine Hornby and Susan Mollan and Hannah Botfield and OʼReilly, {Michael W.} and Alexandra Sinclair",
year = "2018",
month = dec,
doi = "10.1097/WNO.0000000000000684",
language = "English",
volume = "38",
pages = "522–530",
journal = "Journal of Neuro-Ophthalmology",
issn = "1070-8022",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

RIS

TY - JOUR

T1 - Metabolic Concepts in Idiopathic Intracranial Hypertension and Their Potential for Therapeutic Intervention

AU - Hornby, Catherine

AU - Mollan, Susan

AU - Botfield, Hannah

AU - OʼReilly, Michael W.

AU - Sinclair, Alexandra

PY - 2018/12

Y1 - 2018/12

N2 - BACKGROUND: Traditional risk factors associated with idiopathic intracranial hypertension (IIH) include obesity, weight gain, and female sex. The incidence of IIH is increasing and yet the underlying trigger and the fueling pathological mechanisms are still poorly understood.EVIDENCE ACQUISITION: Review of ophthalmology, neurology, general surgery, obesity, endocrinology, nutrition, and neurosurgery literature was made.RESULTS: The facts that implicate sex and obesity in IIH and headache are examined. The role of fat distribution in IIH is questioned, and the concept of adipose tissue functioning as an endocrine organ driving IIH is discussed. The impact of androgen metabolism in IIH is reviewed as is the emerging role of glucagon-like-peptide-1 analogues in modulating intracranial pressure. This introduces the concept of developing targeted disease-modifying therapeutic strategies for IIH.CONCLUSIONS: This review will discuss the possible role of the adipose/gut/brain metabolism axis in IIH and speculate how this may impact the pathogenesis of IIH and therapeutic opportunities.

AB - BACKGROUND: Traditional risk factors associated with idiopathic intracranial hypertension (IIH) include obesity, weight gain, and female sex. The incidence of IIH is increasing and yet the underlying trigger and the fueling pathological mechanisms are still poorly understood.EVIDENCE ACQUISITION: Review of ophthalmology, neurology, general surgery, obesity, endocrinology, nutrition, and neurosurgery literature was made.RESULTS: The facts that implicate sex and obesity in IIH and headache are examined. The role of fat distribution in IIH is questioned, and the concept of adipose tissue functioning as an endocrine organ driving IIH is discussed. The impact of androgen metabolism in IIH is reviewed as is the emerging role of glucagon-like-peptide-1 analogues in modulating intracranial pressure. This introduces the concept of developing targeted disease-modifying therapeutic strategies for IIH.CONCLUSIONS: This review will discuss the possible role of the adipose/gut/brain metabolism axis in IIH and speculate how this may impact the pathogenesis of IIH and therapeutic opportunities.

U2 - 10.1097/WNO.0000000000000684

DO - 10.1097/WNO.0000000000000684

M3 - Article

C2 - 29985799

VL - 38

SP - 522

EP - 530

JO - Journal of Neuro-Ophthalmology

JF - Journal of Neuro-Ophthalmology

SN - 1070-8022

IS - 4

ER -