Mesenchymal stem cells as endogenous regulators of inflammation

Research output: Chapter in Book/Report/Conference proceedingChapter

Authors

Colleges, School and Institutes

Abstract

This chapter discusses the regulatory role of endogenous mesenchymal stem cells (MSC) during an inflammatory response. MSC are a heterogeneous population of multipotent cells that normally contribute towards tissue maintenance and repair but have garnered significant scientific interest for their potent immunomodulatory potential. It is through these physicochemical interactions that MSC are able to exert an anti-inflammatory response on neighbouring stromal and haematopoietic cells. However, the impact of the chronic inflammatory environment on MSC function remains to be determined. Understanding the relationship of MSC between resolution of inflammation and autoimmunity will both offer new insights in the use of MSC as a therapeutic, and also their involvement in the pathogenesis of inflammatory disorders.

Details

Original languageEnglish
Title of host publicationStromal Immunology
Publication statusPublished - 29 Aug 2018

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1060
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Endothelial cells, Lymphocytes, Mesenchymal stem cells, Neutrophils