Memory reconsolidation impairments in sign-tracking to an audiovisual compound stimulus

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Memory reconsolidation impairments in sign-tracking to an audiovisual compound stimulus. / Drame, Mohamed Lamine; Balaet, Maria; Lee, Jonathan.

In: Behavioural Brain Research, Vol. 393, 112774, 01.09.2020.

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@article{bccc8fe8720943bead362b96f3731847,
title = "Memory reconsolidation impairments in sign-tracking to an audiovisual compound stimulus",
abstract = "Studies of memory reconsolidation of pavlovian memories have typically employed unimodal conditioned stimuli, despite the use of multimodal compound stimuli in other settings. Here we studied sign-tracking behaviour to a compound audiovisual stimulus. First, we observed not unexpectedly that sign-tracking was poorer to the audiovisual compound than to unimodal visual stimuli. Then, we showed that, depending on the parameters of compound stimulus re-exposure at memory reactivation, systemic MK-801 treatment either impaired extinction to improve sign-tracking at test, or disrupted reconsolidation to impair test behaviour. When memory reactivation consisted of re-exposure to only the auditory component of the compound stimulus, we observed sign-tracking impairments following MK-801 treatment, but only under certain test conditions. This was in contrast to the consistent impairment following reactivation with the full audiovisual compound. Moreover, the parameters of auditory stimulus presentation to enable MK-801-induced impairment at test varied depending on whether the stimulus was presented within or outside the training context. These findings suggest that behaviour under the control of appetitive pavlovian compound stimuli can be modulated by targeting both extinction and reconsolidation, and that it is not necessary to re-expose to the full compound stimulus in order to achieve a degree of modulation of behaviour.",
keywords = "Autoshaping, Destabilization, Extinction, Pavlovian, Reconsolidation, Sign tracking",
author = "Drame, {Mohamed Lamine} and Maria Balaet and Jonathan Lee",
year = "2020",
month = sep,
day = "1",
doi = "10.1016/j.bbr.2020.112774",
language = "English",
volume = "393",
journal = "Behavioural Brain Research",
issn = "0166-4328",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Memory reconsolidation impairments in sign-tracking to an audiovisual compound stimulus

AU - Drame, Mohamed Lamine

AU - Balaet, Maria

AU - Lee, Jonathan

PY - 2020/9/1

Y1 - 2020/9/1

N2 - Studies of memory reconsolidation of pavlovian memories have typically employed unimodal conditioned stimuli, despite the use of multimodal compound stimuli in other settings. Here we studied sign-tracking behaviour to a compound audiovisual stimulus. First, we observed not unexpectedly that sign-tracking was poorer to the audiovisual compound than to unimodal visual stimuli. Then, we showed that, depending on the parameters of compound stimulus re-exposure at memory reactivation, systemic MK-801 treatment either impaired extinction to improve sign-tracking at test, or disrupted reconsolidation to impair test behaviour. When memory reactivation consisted of re-exposure to only the auditory component of the compound stimulus, we observed sign-tracking impairments following MK-801 treatment, but only under certain test conditions. This was in contrast to the consistent impairment following reactivation with the full audiovisual compound. Moreover, the parameters of auditory stimulus presentation to enable MK-801-induced impairment at test varied depending on whether the stimulus was presented within or outside the training context. These findings suggest that behaviour under the control of appetitive pavlovian compound stimuli can be modulated by targeting both extinction and reconsolidation, and that it is not necessary to re-expose to the full compound stimulus in order to achieve a degree of modulation of behaviour.

AB - Studies of memory reconsolidation of pavlovian memories have typically employed unimodal conditioned stimuli, despite the use of multimodal compound stimuli in other settings. Here we studied sign-tracking behaviour to a compound audiovisual stimulus. First, we observed not unexpectedly that sign-tracking was poorer to the audiovisual compound than to unimodal visual stimuli. Then, we showed that, depending on the parameters of compound stimulus re-exposure at memory reactivation, systemic MK-801 treatment either impaired extinction to improve sign-tracking at test, or disrupted reconsolidation to impair test behaviour. When memory reactivation consisted of re-exposure to only the auditory component of the compound stimulus, we observed sign-tracking impairments following MK-801 treatment, but only under certain test conditions. This was in contrast to the consistent impairment following reactivation with the full audiovisual compound. Moreover, the parameters of auditory stimulus presentation to enable MK-801-induced impairment at test varied depending on whether the stimulus was presented within or outside the training context. These findings suggest that behaviour under the control of appetitive pavlovian compound stimuli can be modulated by targeting both extinction and reconsolidation, and that it is not necessary to re-expose to the full compound stimulus in order to achieve a degree of modulation of behaviour.

KW - Autoshaping

KW - Destabilization

KW - Extinction

KW - Pavlovian

KW - Reconsolidation

KW - Sign tracking

UR - http://www.scopus.com/inward/record.url?scp=85086745882&partnerID=8YFLogxK

U2 - 10.1016/j.bbr.2020.112774

DO - 10.1016/j.bbr.2020.112774

M3 - Article

VL - 393

JO - Behavioural Brain Research

JF - Behavioural Brain Research

SN - 0166-4328

M1 - 112774

ER -