Projects per year
Abstract
The folding of transmembrane proteins into the outer membrane presents formidable challenges to Gram-negative bacteria. These proteins must migrate from the cytoplasm, through the inner membrane and into the periplasm, before being recognized by the beta-barrel assembly machinery, which mediates efficient insertion of folded beta-barrels into the outer membrane. Recent discoveries of component structures and accessory interactions of this complex are yielding insights into how cells fold membrane proteins. Here, we discuss how these structures illuminate the mechanisms responsible for the biogenesis of outer membrane proteins.
Original language | English |
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Pages (from-to) | 206-14 |
Number of pages | 9 |
Journal | Nature Reviews Microbiology |
Volume | 7 |
Issue number | 3 |
DOIs | |
Publication status | Published - 1 Mar 2009 |
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Dive into the research topics of 'Membrane protein architects: the role of the BAM complex in outer membrane protein assembly.'. Together they form a unique fingerprint.Projects
- 3 Finished
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Structural Basis of the Outer Membrane Protein Assembly System by NMR Spectroscopy
Overduin, M., Henderson, I. & Knowles, T.
Biotechnology & Biological Sciences Research Council
1/12/09 → 30/11/13
Project: Research Councils
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POTRA Domain Structure and Function by NMR Spectroscopy
Overduin, M. & Henderson, I.
Biotechnology & Biological Sciences Research Council
1/10/07 → 30/09/10
Project: Research Councils
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Understanding Events at the Cell Surface During Autotransporter Biogenesis
Henderson, I. & Overduin, M.
10/09/07 → 9/04/11
Project: Research Councils