Melatonin Receptor Expression in the Zebra Finch Brain and Peripheral Tissues

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Melatonin Receptor Expression in the Zebra Finch Brain and Peripheral Tissues. / Jones, C; Helfer, G; Brandstaetter, Roland.

In: Chronobiology International, Vol. 29, No. 2, 01.01.2012, p. 189-202.

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@article{d58282c92f354e629c89c9a7fe210074,
title = "Melatonin Receptor Expression in the Zebra Finch Brain and Peripheral Tissues",
abstract = "The circadian endocrine hormone melatonin plays a significant role in many physiological processes such as modulating sleep/wake cycle and oxidative stress. Melatonin is synthesised and secreted during the night by the pineal gland and released into the circulatory system. It binds to numerous membrane, cytosolic and nuclear receptors in the brain and peripheral organs. Three G-protein linked membrane receptors (Mel-1A, Mel-1B and Mel-1C) have been identified in numerous species. Considering the importance of this hormone and its receptors, this study looks at the location and rhythmicity of three avian melatonin receptors Mel-1A, Mel-1B and Mel-1C using reserve transcription-polymerase chain reaction (RT-PCR) mRNA analysis techniques. This study shows successful partial cloning of the three receptors and gene expression analysis revealed significant rhythms of the Mel-1A receptor in the cerebellum, diencephalon, tectum opticum, telencephalon, and retina. Significant rhythms where found in the diencephalon, pineal gland, retina, tectum opticum and cerebellum of the Mel-1B receptor whereas Mel-1C appeared not to be rhythmically expressed in brain tissues studied. Mel-1A, Mel-1B and Mel-1C receptor mRNA where also present in peripheral tissues showing tissue-specific expression patterns.",
keywords = "Brain, Pineal gland circadian rhythm, Melatonin receptors",
author = "C Jones and G Helfer and Roland Brandstaetter",
year = "2012",
month = jan,
day = "1",
doi = "10.3109/07420528.2011.642912",
language = "English",
volume = "29",
pages = "189--202",
journal = "Chronobiology International",
issn = "0742-0528",
publisher = "Taylor & Francis",
number = "2",

}

RIS

TY - JOUR

T1 - Melatonin Receptor Expression in the Zebra Finch Brain and Peripheral Tissues

AU - Jones, C

AU - Helfer, G

AU - Brandstaetter, Roland

PY - 2012/1/1

Y1 - 2012/1/1

N2 - The circadian endocrine hormone melatonin plays a significant role in many physiological processes such as modulating sleep/wake cycle and oxidative stress. Melatonin is synthesised and secreted during the night by the pineal gland and released into the circulatory system. It binds to numerous membrane, cytosolic and nuclear receptors in the brain and peripheral organs. Three G-protein linked membrane receptors (Mel-1A, Mel-1B and Mel-1C) have been identified in numerous species. Considering the importance of this hormone and its receptors, this study looks at the location and rhythmicity of three avian melatonin receptors Mel-1A, Mel-1B and Mel-1C using reserve transcription-polymerase chain reaction (RT-PCR) mRNA analysis techniques. This study shows successful partial cloning of the three receptors and gene expression analysis revealed significant rhythms of the Mel-1A receptor in the cerebellum, diencephalon, tectum opticum, telencephalon, and retina. Significant rhythms where found in the diencephalon, pineal gland, retina, tectum opticum and cerebellum of the Mel-1B receptor whereas Mel-1C appeared not to be rhythmically expressed in brain tissues studied. Mel-1A, Mel-1B and Mel-1C receptor mRNA where also present in peripheral tissues showing tissue-specific expression patterns.

AB - The circadian endocrine hormone melatonin plays a significant role in many physiological processes such as modulating sleep/wake cycle and oxidative stress. Melatonin is synthesised and secreted during the night by the pineal gland and released into the circulatory system. It binds to numerous membrane, cytosolic and nuclear receptors in the brain and peripheral organs. Three G-protein linked membrane receptors (Mel-1A, Mel-1B and Mel-1C) have been identified in numerous species. Considering the importance of this hormone and its receptors, this study looks at the location and rhythmicity of three avian melatonin receptors Mel-1A, Mel-1B and Mel-1C using reserve transcription-polymerase chain reaction (RT-PCR) mRNA analysis techniques. This study shows successful partial cloning of the three receptors and gene expression analysis revealed significant rhythms of the Mel-1A receptor in the cerebellum, diencephalon, tectum opticum, telencephalon, and retina. Significant rhythms where found in the diencephalon, pineal gland, retina, tectum opticum and cerebellum of the Mel-1B receptor whereas Mel-1C appeared not to be rhythmically expressed in brain tissues studied. Mel-1A, Mel-1B and Mel-1C receptor mRNA where also present in peripheral tissues showing tissue-specific expression patterns.

KW - Brain

KW - Pineal gland circadian rhythm

KW - Melatonin receptors

U2 - 10.3109/07420528.2011.642912

DO - 10.3109/07420528.2011.642912

M3 - Article

C2 - 22324557

VL - 29

SP - 189

EP - 202

JO - Chronobiology International

JF - Chronobiology International

SN - 0742-0528

IS - 2

ER -