Medicinal Organometallic Chemistry: Designing Metal Arene Complexes as Anticancer Agents

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Medicinal Organometallic Chemistry: Designing Metal Arene Complexes as Anticancer Agents. / Peacock, Anna; Sadler, PJ.

In: Chemistry - An Asian Journal, Vol. 3, No. 11, 01.01.2008, p. 1890-1899.

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@article{aca6f1a5eb404190a23d47d061a6022e,
title = "Medicinal Organometallic Chemistry: Designing Metal Arene Complexes as Anticancer Agents",
abstract = "The field of medicinal inorganic chemistry is rapidly advancing. In particular organometallic complexes have much potential as therapeutic and diagnostic agents. The carbon-bound and other ligands allow the thermodynamic and kinetic reactivity of the metal ion to be controlled and also provide a scaffold for functionalization. The establishment of structure-activity relationships and elucidation of the speciation of complexes under conditions relevant to drug testing and formulation are crucial for the further development of promising medicinal applications of organometallic complexes. Specific examples involving the design of ruthenium and osmium arene complexes as anticancer agents are discussed.",
keywords = "organometallics, arene ligands, anticancer agents, osmium, ruthenium",
author = "Anna Peacock and PJ Sadler",
year = "2008",
month = jan,
day = "1",
doi = "10.1002/asia.200800149",
language = "English",
volume = "3",
pages = "1890--1899",
journal = "Chemistry - An Asian Journal",
issn = "1861-4728",
publisher = "Wiley-VCH Verlag",
number = "11",

}

RIS

TY - JOUR

T1 - Medicinal Organometallic Chemistry: Designing Metal Arene Complexes as Anticancer Agents

AU - Peacock, Anna

AU - Sadler, PJ

PY - 2008/1/1

Y1 - 2008/1/1

N2 - The field of medicinal inorganic chemistry is rapidly advancing. In particular organometallic complexes have much potential as therapeutic and diagnostic agents. The carbon-bound and other ligands allow the thermodynamic and kinetic reactivity of the metal ion to be controlled and also provide a scaffold for functionalization. The establishment of structure-activity relationships and elucidation of the speciation of complexes under conditions relevant to drug testing and formulation are crucial for the further development of promising medicinal applications of organometallic complexes. Specific examples involving the design of ruthenium and osmium arene complexes as anticancer agents are discussed.

AB - The field of medicinal inorganic chemistry is rapidly advancing. In particular organometallic complexes have much potential as therapeutic and diagnostic agents. The carbon-bound and other ligands allow the thermodynamic and kinetic reactivity of the metal ion to be controlled and also provide a scaffold for functionalization. The establishment of structure-activity relationships and elucidation of the speciation of complexes under conditions relevant to drug testing and formulation are crucial for the further development of promising medicinal applications of organometallic complexes. Specific examples involving the design of ruthenium and osmium arene complexes as anticancer agents are discussed.

KW - organometallics

KW - arene ligands

KW - anticancer agents

KW - osmium

KW - ruthenium

U2 - 10.1002/asia.200800149

DO - 10.1002/asia.200800149

M3 - Review article

C2 - 18712745

VL - 3

SP - 1890

EP - 1899

JO - Chemistry - An Asian Journal

JF - Chemistry - An Asian Journal

SN - 1861-4728

IS - 11

ER -