Medicinal Organometallic Chemistry: Designing Metal Arene Complexes as Anticancer Agents

Research output: Contribution to journalReview article

Authors

Colleges, School and Institutes

Abstract

The field of medicinal inorganic chemistry is rapidly advancing. In particular organometallic complexes have much potential as therapeutic and diagnostic agents. The carbon-bound and other ligands allow the thermodynamic and kinetic reactivity of the metal ion to be controlled and also provide a scaffold for functionalization. The establishment of structure-activity relationships and elucidation of the speciation of complexes under conditions relevant to drug testing and formulation are crucial for the further development of promising medicinal applications of organometallic complexes. Specific examples involving the design of ruthenium and osmium arene complexes as anticancer agents are discussed.

Details

Original languageEnglish
Pages (from-to)1890-1899
Number of pages10
JournalChemistry - An Asian Journal
Volume3
Issue number11
Publication statusPublished - 1 Jan 2008

Keywords

  • organometallics, arene ligands, anticancer agents, osmium, ruthenium