Mechanisms of tissue injury in autoimmune liver diseases

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Mechanisms of tissue injury in autoimmune liver diseases. / Liaskou, Evaggelia; Hirschfield, Gideon M; Gershwin, M Eric.

In: Seminars in immunopathology, Vol. 36, No. 5, 09.2014, p. 553-568.

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@article{0803cbf6433f49bc873d37b2fa5279f1,
title = "Mechanisms of tissue injury in autoimmune liver diseases",
abstract = "Autoimmune diseases affecting the liver are mainly represented by autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC). The characteristic morphologic patterns of injury are a chronic hepatitis pattern of damage in AIH, destruction of small intrahepatic bile ducts in PBC and periductal fibrosis and inflammation involving larger bile ducts in PSC. The factors responsible for initiation and perpetuation of the injury in all the three autoimmune liver diseases are not understood completely but are likely to be environmental triggers on the background of genetic variation in immune regulation. In this review, we summarise the current understanding of the mechanisms underlying the breakdown of self-tolerance in autoimmune liver diseases.",
keywords = "Animals, Autoimmune Diseases, Disease Models, Animal, Humans, Liver Diseases",
author = "Evaggelia Liaskou and Hirschfield, {Gideon M} and Gershwin, {M Eric}",
year = "2014",
month = sep,
doi = "10.1007/s00281-014-0439-3",
language = "English",
volume = "36",
pages = "553--568",
journal = "Seminars in immunopathology",
issn = "1863-2297",
publisher = "Springer",
number = "5",

}

RIS

TY - JOUR

T1 - Mechanisms of tissue injury in autoimmune liver diseases

AU - Liaskou, Evaggelia

AU - Hirschfield, Gideon M

AU - Gershwin, M Eric

PY - 2014/9

Y1 - 2014/9

N2 - Autoimmune diseases affecting the liver are mainly represented by autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC). The characteristic morphologic patterns of injury are a chronic hepatitis pattern of damage in AIH, destruction of small intrahepatic bile ducts in PBC and periductal fibrosis and inflammation involving larger bile ducts in PSC. The factors responsible for initiation and perpetuation of the injury in all the three autoimmune liver diseases are not understood completely but are likely to be environmental triggers on the background of genetic variation in immune regulation. In this review, we summarise the current understanding of the mechanisms underlying the breakdown of self-tolerance in autoimmune liver diseases.

AB - Autoimmune diseases affecting the liver are mainly represented by autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC). The characteristic morphologic patterns of injury are a chronic hepatitis pattern of damage in AIH, destruction of small intrahepatic bile ducts in PBC and periductal fibrosis and inflammation involving larger bile ducts in PSC. The factors responsible for initiation and perpetuation of the injury in all the three autoimmune liver diseases are not understood completely but are likely to be environmental triggers on the background of genetic variation in immune regulation. In this review, we summarise the current understanding of the mechanisms underlying the breakdown of self-tolerance in autoimmune liver diseases.

KW - Animals

KW - Autoimmune Diseases

KW - Disease Models, Animal

KW - Humans

KW - Liver Diseases

U2 - 10.1007/s00281-014-0439-3

DO - 10.1007/s00281-014-0439-3

M3 - Article

C2 - 25082647

VL - 36

SP - 553

EP - 568

JO - Seminars in immunopathology

JF - Seminars in immunopathology

SN - 1863-2297

IS - 5

ER -