Mechanisms of thymus medulla development and function

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@article{d70df31981e44fcbae72dccac8d2928f,
title = "Mechanisms of thymus medulla development and function",
abstract = "The development of CD4(+) helper and CD8(+) cytotoxic T-cells expressing the αβ form of the T-cell receptor (αβTCR) takes place in the thymus, a primary lymphoid organ containing distinct cortical and medullary microenvironments. While the cortex represents a site of early T-cell precursor development, and the positive selection of CD4(+)8(+) thymocytes, the thymic medulla plays a key role in tolerance induction, ensuring that thymic emigrants are purged of autoreactive αβTCR specificities. In recent years, advances have been made in understanding the development and function of thymic medullary epithelial cells, most notably the subset defined by expression of the Autoimmune Regulator (Aire) gene. Here, we summarize current knowledge of the developmental mechanisms regulating thymus medulla development, and examine the role of the thymus medulla in recessive (negative selection) and dominant (T-regulatory cell) tolerance.",
keywords = "Animals, Cell Differentiation, Cell Lineage, Epithelial Cells, Hematopoietic Stem Cells, Humans, Immune Tolerance, T-Lymphocytes, Regulatory, Thymus Gland",
author = "Graham Anderson and Song Baik and Cowan, {Jennifer E} and Holland, {Amanda M} and McCarthy, {Nicholas I} and Kyoko Nakamura and Parnell, {Sonia M} and White, {Andrea J} and Lane, {Peter J L} and Jenkinson, {Eric J} and Jenkinson, {William E}",
year = "2014",
doi = "10.1007/82_2013_320",
language = "English",
volume = "373",
pages = "19--47",
journal = "Current Topics in Microbiology and Immunology",
issn = "0070-217X",
publisher = "Springer",

}

RIS

TY - JOUR

T1 - Mechanisms of thymus medulla development and function

AU - Anderson, Graham

AU - Baik, Song

AU - Cowan, Jennifer E

AU - Holland, Amanda M

AU - McCarthy, Nicholas I

AU - Nakamura, Kyoko

AU - Parnell, Sonia M

AU - White, Andrea J

AU - Lane, Peter J L

AU - Jenkinson, Eric J

AU - Jenkinson, William E

PY - 2014

Y1 - 2014

N2 - The development of CD4(+) helper and CD8(+) cytotoxic T-cells expressing the αβ form of the T-cell receptor (αβTCR) takes place in the thymus, a primary lymphoid organ containing distinct cortical and medullary microenvironments. While the cortex represents a site of early T-cell precursor development, and the positive selection of CD4(+)8(+) thymocytes, the thymic medulla plays a key role in tolerance induction, ensuring that thymic emigrants are purged of autoreactive αβTCR specificities. In recent years, advances have been made in understanding the development and function of thymic medullary epithelial cells, most notably the subset defined by expression of the Autoimmune Regulator (Aire) gene. Here, we summarize current knowledge of the developmental mechanisms regulating thymus medulla development, and examine the role of the thymus medulla in recessive (negative selection) and dominant (T-regulatory cell) tolerance.

AB - The development of CD4(+) helper and CD8(+) cytotoxic T-cells expressing the αβ form of the T-cell receptor (αβTCR) takes place in the thymus, a primary lymphoid organ containing distinct cortical and medullary microenvironments. While the cortex represents a site of early T-cell precursor development, and the positive selection of CD4(+)8(+) thymocytes, the thymic medulla plays a key role in tolerance induction, ensuring that thymic emigrants are purged of autoreactive αβTCR specificities. In recent years, advances have been made in understanding the development and function of thymic medullary epithelial cells, most notably the subset defined by expression of the Autoimmune Regulator (Aire) gene. Here, we summarize current knowledge of the developmental mechanisms regulating thymus medulla development, and examine the role of the thymus medulla in recessive (negative selection) and dominant (T-regulatory cell) tolerance.

KW - Animals

KW - Cell Differentiation

KW - Cell Lineage

KW - Epithelial Cells

KW - Hematopoietic Stem Cells

KW - Humans

KW - Immune Tolerance

KW - T-Lymphocytes, Regulatory

KW - Thymus Gland

U2 - 10.1007/82_2013_320

DO - 10.1007/82_2013_320

M3 - Article

C2 - 23612988

VL - 373

SP - 19

EP - 47

JO - Current Topics in Microbiology and Immunology

JF - Current Topics in Microbiology and Immunology

SN - 0070-217X

ER -