Mechanisms of oncogene-induced replication stress: jigsaw falling into place

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Mechanisms of oncogene-induced replication stress : jigsaw falling into place. / Kotsantis, Panagiotis; Petermann, Eva; Boulton, Simon J.

In: Cancer Discovery, Vol. 8, No. 5, 05.2018, p. 537-555.

Research output: Contribution to journalReview articlepeer-review

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Kotsantis, Panagiotis ; Petermann, Eva ; Boulton, Simon J. / Mechanisms of oncogene-induced replication stress : jigsaw falling into place. In: Cancer Discovery. 2018 ; Vol. 8, No. 5. pp. 537-555.

Bibtex

@article{4909ca2856034c7f91a3c592ad8f077f,
title = "Mechanisms of oncogene-induced replication stress: jigsaw falling into place",
abstract = "Oncogene activation disturbs cellular processes and accommodates a complex landscape of changes in the genome that contribute to genomic instability, which accelerates mutation rates and promotes tumorigenesis. Part of this cellular turmoil involves deregulation of physiologic DNA replication, widely described as replication stress. Oncogene-induced replication stress is an early driver of genomic instability and is attributed to a plethora of factors, most notably aberrant origin firing, replication-transcription collisions, reactive oxygen species, and defective nucleotide metabolism.Significance: Replication stress is a fundamental step and an early driver of tumorigenesis and has been associated with many activated oncogenes. Deciphering the mechanisms that contribute to the replication stress response may provide new avenues for targeted cancer treatment. In this review, we discuss the latest findings on the DNA replication stress response and examine the various mechanisms through which activated oncogenes induce replication stress.",
keywords = "DNA replication stress , oncogenes , genomic instability , cancer",
author = "Panagiotis Kotsantis and Eva Petermann and Boulton, {Simon J.}",
note = "{\textcopyright}2018 American Association for Cancer Research.",
year = "2018",
month = may,
doi = "10.1158/2159-8290.CD-17-1461",
language = "English",
volume = "8",
pages = "537--555",
journal = "Cancer Discovery",
issn = "2159-8274",
publisher = "American Association for Cancer Research",
number = "5",

}

RIS

TY - JOUR

T1 - Mechanisms of oncogene-induced replication stress

T2 - jigsaw falling into place

AU - Kotsantis, Panagiotis

AU - Petermann, Eva

AU - Boulton, Simon J.

N1 - ©2018 American Association for Cancer Research.

PY - 2018/5

Y1 - 2018/5

N2 - Oncogene activation disturbs cellular processes and accommodates a complex landscape of changes in the genome that contribute to genomic instability, which accelerates mutation rates and promotes tumorigenesis. Part of this cellular turmoil involves deregulation of physiologic DNA replication, widely described as replication stress. Oncogene-induced replication stress is an early driver of genomic instability and is attributed to a plethora of factors, most notably aberrant origin firing, replication-transcription collisions, reactive oxygen species, and defective nucleotide metabolism.Significance: Replication stress is a fundamental step and an early driver of tumorigenesis and has been associated with many activated oncogenes. Deciphering the mechanisms that contribute to the replication stress response may provide new avenues for targeted cancer treatment. In this review, we discuss the latest findings on the DNA replication stress response and examine the various mechanisms through which activated oncogenes induce replication stress.

AB - Oncogene activation disturbs cellular processes and accommodates a complex landscape of changes in the genome that contribute to genomic instability, which accelerates mutation rates and promotes tumorigenesis. Part of this cellular turmoil involves deregulation of physiologic DNA replication, widely described as replication stress. Oncogene-induced replication stress is an early driver of genomic instability and is attributed to a plethora of factors, most notably aberrant origin firing, replication-transcription collisions, reactive oxygen species, and defective nucleotide metabolism.Significance: Replication stress is a fundamental step and an early driver of tumorigenesis and has been associated with many activated oncogenes. Deciphering the mechanisms that contribute to the replication stress response may provide new avenues for targeted cancer treatment. In this review, we discuss the latest findings on the DNA replication stress response and examine the various mechanisms through which activated oncogenes induce replication stress.

KW - DNA replication stress

KW - oncogenes

KW - genomic instability

KW - cancer

U2 - 10.1158/2159-8290.CD-17-1461

DO - 10.1158/2159-8290.CD-17-1461

M3 - Review article

C2 - 29653955

VL - 8

SP - 537

EP - 555

JO - Cancer Discovery

JF - Cancer Discovery

SN - 2159-8274

IS - 5

ER -