Mechanisms of oncogene-induced replication stress: jigsaw falling into place
Research output: Contribution to journal › Review article › peer-review
Colleges, School and Institutes
- The Francis Crick Institute
Oncogene activation disturbs cellular processes and accommodates a complex landscape of changes in the genome that contribute to genomic instability, which accelerates mutation rates and promotes tumorigenesis. Part of this cellular turmoil involves deregulation of physiologic DNA replication, widely described as replication stress. Oncogene-induced replication stress is an early driver of genomic instability and is attributed to a plethora of factors, most notably aberrant origin firing, replication-transcription collisions, reactive oxygen species, and defective nucleotide metabolism.
Significance: Replication stress is a fundamental step and an early driver of tumorigenesis and has been associated with many activated oncogenes. Deciphering the mechanisms that contribute to the replication stress response may provide new avenues for targeted cancer treatment. In this review, we discuss the latest findings on the DNA replication stress response and examine the various mechanisms through which activated oncogenes induce replication stress.
|Number of pages||19|
|Early online date||13 Apr 2018|
|Publication status||Published - May 2018|
- DNA replication stress , oncogenes , genomic instability , cancer