Abstract
The inhibition of DNA synthesis by sparfloxacin; accumulation of sparfloxacin into members of the family Enterobacteriaceae, Pseudomonas aeruginosa, and staphylococci; induction of recA in Escherichia coli; and the optimum bactericidal concentration (OBC) were measured, and killing kinetics at the OBC were estimated. The OBC and maximum recA-inducing concentration in E. coli were both 1 microgram of sparfloxacin per ml. Accumulation was rapid; two- to threefold more sparfloxacin than ciprofloxacin accumulated in staphylococci and more sparfloxacin accumulated in staphylococci than in gram-negative bacteria. Laboratory mutants with decreased susceptibilities to quinolones alone or multiply resistant were selected from the Enterobacteriaceae and Staphylococcus aureus by using sparfloxacin.
| Original language | English |
|---|---|
| Pages (from-to) | 2423-7 |
| Number of pages | 5 |
| Journal | Antimicrobial Agents and Chemotherapy |
| Volume | 35 |
| Issue number | 11 |
| Publication status | Published - Nov 1991 |
Keywords
- Anti-Bacterial Agents
- Ciprofloxacin
- DNA Probes
- DNA, Bacterial
- Drug Resistance, Microbial
- Enterobacteriaceae
- Fluoroquinolones
- Gram-Negative Bacteria
- Gram-Positive Bacteria
- Mutation
- Phenotype
- Pseudomonas aeruginosa
- Quinolones