Mcl-1 expression has in vitro and in vivo significance in chronic lymphocytic leukemia and is associated with other poor prognostic markers

Research output: Contribution to journalArticle

Authors

  • C Pepper
  • TT Lin
  • S Hewamana
  • P Brennan
  • L Hiller
  • R Hills
  • R Ward
  • J Starczynski
  • B Austen
  • L Hooper
  • C Fegan

Colleges, School and Institutes

Abstract

Bcl-2 family proteins play a critical role in the regulation of apoptosis in chronic lymphocytic leukemia (CLL). However, their association with established prognostic markers is unknown. In this study, we analyzed the expression of Bcl-2, Bax, and Mcl-1 in 185 CLL patients and evaluated their relationship with other prognostic markers, in vitro sensitivity to fludarabine, and clinical outcome. Mcl-1 expression was significantly correlated with stage of disease (P

Details

Original languageEnglish
Pages (from-to)3807-3817
Number of pages11
JournalBlood
Volume112
Issue number9
Publication statusPublished - 1 Nov 2008