Maternal hypothyroidism in mice influences glucose metabolism in adult offspring

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Maternal hypothyroidism in mice influences glucose metabolism in adult offspring. / Kemkem, Yasmine; Nasteska, Daniela; De Bray, Annie; Bargi-Souza, Paula; Peliciari-Garcia, Rodrigo; Guillou, Anne; Mollard, Patrice; Hodson, David; Schaeffer, Marie.

In: Diabetologia, 30.05.2020.

Research output: Contribution to journalArticlepeer-review

Harvard

Kemkem, Y, Nasteska, D, De Bray, A, Bargi-Souza, P, Peliciari-Garcia, R, Guillou, A, Mollard, P, Hodson, D & Schaeffer, M 2020, 'Maternal hypothyroidism in mice influences glucose metabolism in adult offspring', Diabetologia. https://doi.org/10.1007/s00125-020-05172-x

APA

Kemkem, Y., Nasteska, D., De Bray, A., Bargi-Souza, P., Peliciari-Garcia, R., Guillou, A., Mollard, P., Hodson, D., & Schaeffer, M. (2020). Maternal hypothyroidism in mice influences glucose metabolism in adult offspring. Diabetologia. https://doi.org/10.1007/s00125-020-05172-x

Vancouver

Author

Kemkem, Yasmine ; Nasteska, Daniela ; De Bray, Annie ; Bargi-Souza, Paula ; Peliciari-Garcia, Rodrigo ; Guillou, Anne ; Mollard, Patrice ; Hodson, David ; Schaeffer, Marie. / Maternal hypothyroidism in mice influences glucose metabolism in adult offspring. In: Diabetologia. 2020.

Bibtex

@article{40b7ac79835f4ecd9f1b07a4b41370c8,
title = "Maternal hypothyroidism in mice influences glucose metabolism in adult offspring",
abstract = "Aims/hypothesisDuring pregnancy, maternal metabolic disease and hormonal imbalance may alter fetal beta cell development and/or proliferation, thus leading to an increased risk for developing type 2 diabetes in adulthood. Although thyroid hormones play an important role in fetal endocrine pancreas development, the impact of maternal hypothyroidism on glucose homeostasis in adult offspring remains poorly understood.MethodsWe investigated this using a mouse model of hypothyroidism, induced by administration of an iodine-deficient diet supplemented with propylthiouracil during gestation.ResultsHere, we show that, when fed normal chow, adult mice born to hypothyroid mothers were more glucose-tolerant due to beta cell hyperproliferation (two- to threefold increase in Ki67-positive beta cells) and increased insulin sensitivity. However, following 8 weeks of high-fat feeding, these offspring gained 20% more body weight, became profoundly hyperinsulinaemic (with a 50% increase in fasting insulin concentration), insulin-resistant and glucose-intolerant compared with controls from euthyroid mothers. Furthermore, altered glucose metabolism was maintained in a second generation of animals.Conclusions/interpretationTherefore, gestational hypothyroidism induces long-term alterations in endocrine pancreas function, which may have implications for type 2 diabetes prevention in affected individuals.",
keywords = "Beta cell function, calcium imaging, diabetes, hypothyroidism, pancreas",
author = "Yasmine Kemkem and Daniela Nasteska and {De Bray}, Annie and Paula Bargi-Souza and Rodrigo Peliciari-Garcia and Anne Guillou and Patrice Mollard and David Hodson and Marie Schaeffer",
year = "2020",
month = may,
day = "30",
doi = "10.1007/s00125-020-05172-x",
language = "English",
journal = "Diabetologia",
issn = "0012-186X",
publisher = "Springer",

}

RIS

TY - JOUR

T1 - Maternal hypothyroidism in mice influences glucose metabolism in adult offspring

AU - Kemkem, Yasmine

AU - Nasteska, Daniela

AU - De Bray, Annie

AU - Bargi-Souza, Paula

AU - Peliciari-Garcia, Rodrigo

AU - Guillou, Anne

AU - Mollard, Patrice

AU - Hodson, David

AU - Schaeffer, Marie

PY - 2020/5/30

Y1 - 2020/5/30

N2 - Aims/hypothesisDuring pregnancy, maternal metabolic disease and hormonal imbalance may alter fetal beta cell development and/or proliferation, thus leading to an increased risk for developing type 2 diabetes in adulthood. Although thyroid hormones play an important role in fetal endocrine pancreas development, the impact of maternal hypothyroidism on glucose homeostasis in adult offspring remains poorly understood.MethodsWe investigated this using a mouse model of hypothyroidism, induced by administration of an iodine-deficient diet supplemented with propylthiouracil during gestation.ResultsHere, we show that, when fed normal chow, adult mice born to hypothyroid mothers were more glucose-tolerant due to beta cell hyperproliferation (two- to threefold increase in Ki67-positive beta cells) and increased insulin sensitivity. However, following 8 weeks of high-fat feeding, these offspring gained 20% more body weight, became profoundly hyperinsulinaemic (with a 50% increase in fasting insulin concentration), insulin-resistant and glucose-intolerant compared with controls from euthyroid mothers. Furthermore, altered glucose metabolism was maintained in a second generation of animals.Conclusions/interpretationTherefore, gestational hypothyroidism induces long-term alterations in endocrine pancreas function, which may have implications for type 2 diabetes prevention in affected individuals.

AB - Aims/hypothesisDuring pregnancy, maternal metabolic disease and hormonal imbalance may alter fetal beta cell development and/or proliferation, thus leading to an increased risk for developing type 2 diabetes in adulthood. Although thyroid hormones play an important role in fetal endocrine pancreas development, the impact of maternal hypothyroidism on glucose homeostasis in adult offspring remains poorly understood.MethodsWe investigated this using a mouse model of hypothyroidism, induced by administration of an iodine-deficient diet supplemented with propylthiouracil during gestation.ResultsHere, we show that, when fed normal chow, adult mice born to hypothyroid mothers were more glucose-tolerant due to beta cell hyperproliferation (two- to threefold increase in Ki67-positive beta cells) and increased insulin sensitivity. However, following 8 weeks of high-fat feeding, these offspring gained 20% more body weight, became profoundly hyperinsulinaemic (with a 50% increase in fasting insulin concentration), insulin-resistant and glucose-intolerant compared with controls from euthyroid mothers. Furthermore, altered glucose metabolism was maintained in a second generation of animals.Conclusions/interpretationTherefore, gestational hypothyroidism induces long-term alterations in endocrine pancreas function, which may have implications for type 2 diabetes prevention in affected individuals.

KW - Beta cell function

KW - calcium imaging

KW - diabetes

KW - hypothyroidism

KW - pancreas

U2 - 10.1007/s00125-020-05172-x

DO - 10.1007/s00125-020-05172-x

M3 - Article

JO - Diabetologia

JF - Diabetologia

SN - 0012-186X

ER -