MAP kinase phosphatase 1: A novel mediator of biological effects of glucocorticoids?

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MAP kinase phosphatase 1 : A novel mediator of biological effects of glucocorticoids? / Clark, Andy R.

In: Journal of Endocrinology, Vol. 178, No. 1, 01.07.2003, p. 5-12.

Research output: Contribution to journalReview articlepeer-review

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@article{981351ca9b4e469389d67e87bcdc3f6d,
title = "MAP kinase phosphatase 1: A novel mediator of biological effects of glucocorticoids?",
abstract = "Synthetic glucocorticoids (GCs) potently inhibit the expression of pro-inflammatory genes and are widely used in the treatment of inflammatory diseases. However, some patients are resistant to the therapeutic effects of GCs, and many suffer deleterious side effects from these drugs. Furthermore, the precise mechanisms by which GCs inhibit pro-inflammatory gene expression remain unclear. A number of recent papers report that GCs induce the sustained expression of MAP kinase (MAPK) phosphatase 1 (MKP-1), a negative regulator of MAPK signal transduction pathways. The potential relevance of MKP-1 to some of the biological effects of GCs is discussed.",
author = "Clark, {Andy R.}",
year = "2003",
month = jul,
day = "1",
doi = "10.1677/joe.0.1780005",
language = "English",
volume = "178",
pages = "5--12",
journal = "Journal of Endocrinology",
issn = "0022-0795",
publisher = "BioScientifica",
number = "1",

}

RIS

TY - JOUR

T1 - MAP kinase phosphatase 1

T2 - A novel mediator of biological effects of glucocorticoids?

AU - Clark, Andy R.

PY - 2003/7/1

Y1 - 2003/7/1

N2 - Synthetic glucocorticoids (GCs) potently inhibit the expression of pro-inflammatory genes and are widely used in the treatment of inflammatory diseases. However, some patients are resistant to the therapeutic effects of GCs, and many suffer deleterious side effects from these drugs. Furthermore, the precise mechanisms by which GCs inhibit pro-inflammatory gene expression remain unclear. A number of recent papers report that GCs induce the sustained expression of MAP kinase (MAPK) phosphatase 1 (MKP-1), a negative regulator of MAPK signal transduction pathways. The potential relevance of MKP-1 to some of the biological effects of GCs is discussed.

AB - Synthetic glucocorticoids (GCs) potently inhibit the expression of pro-inflammatory genes and are widely used in the treatment of inflammatory diseases. However, some patients are resistant to the therapeutic effects of GCs, and many suffer deleterious side effects from these drugs. Furthermore, the precise mechanisms by which GCs inhibit pro-inflammatory gene expression remain unclear. A number of recent papers report that GCs induce the sustained expression of MAP kinase (MAPK) phosphatase 1 (MKP-1), a negative regulator of MAPK signal transduction pathways. The potential relevance of MKP-1 to some of the biological effects of GCs is discussed.

UR - http://www.scopus.com/inward/record.url?scp=0041669330&partnerID=8YFLogxK

U2 - 10.1677/joe.0.1780005

DO - 10.1677/joe.0.1780005

M3 - Review article

C2 - 12844330

AN - SCOPUS:0041669330

VL - 178

SP - 5

EP - 12

JO - Journal of Endocrinology

JF - Journal of Endocrinology

SN - 0022-0795

IS - 1

ER -