MAP kinase phosphatase 1: A novel mediator of biological effects of glucocorticoids?

Research output: Contribution to journalReview articlepeer-review

Colleges, School and Institutes

External organisations

  • Kennedy Institute of Rheumatology Division
  • Imperial College London

Abstract

Synthetic glucocorticoids (GCs) potently inhibit the expression of pro-inflammatory genes and are widely used in the treatment of inflammatory diseases. However, some patients are resistant to the therapeutic effects of GCs, and many suffer deleterious side effects from these drugs. Furthermore, the precise mechanisms by which GCs inhibit pro-inflammatory gene expression remain unclear. A number of recent papers report that GCs induce the sustained expression of MAP kinase (MAPK) phosphatase 1 (MKP-1), a negative regulator of MAPK signal transduction pathways. The potential relevance of MKP-1 to some of the biological effects of GCs is discussed.

Details

Original languageEnglish
Pages (from-to)5-12
Number of pages8
JournalJournal of Endocrinology
Volume178
Issue number1
Publication statusPublished - 1 Jul 2003