Manually curated transcriptomics data collection for toxicogenomic assessment of engineered nanomaterials

Laura Aliisa Saarimäki; Antonio Federico; Iseult Lynch; Anastasios G. Papadiamantis; Andreas Tsoumanis; Georgia Melagraki; Antreas Afantitis; Angela Serra; Dario Greco

doi:10.1038/s41597-021-00808-y

Manually curated transcriptomics data collection for toxicogenomic assessment of engineered nanomaterials

Laura Aliisa Saarimäki, Antonio Federico, Iseult Lynch, Anastasios G. Papadiamantis, Andreas Tsoumanis, Georgia Melagraki, Antreas Afantitis, Angela Serra, Dario Greco

Earth and Environmental Sciences

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Abstract

Toxicogenomics (TGx) approaches are increasingly applied to gain insight into the possible toxicity mechanisms of engineered nanomaterials (ENMs). Omics data can be valuable to elucidate the mechanism of action of chemicals and to develop predictive models in toxicology. While vast amounts of transcriptomics data from ENM exposures have already been accumulated, a unified, easily accessible and reusable collection of transcriptomics data for ENMs is currently lacking. In an attempt to improve the FAIRness of already existing transcriptomics data for ENMs, we curated a collection of homogenized transcriptomics data from human, mouse and rat ENM exposures in vitro and in vivo including the physicochemical characteristics of the ENMs used in each study.

Original language	English
Article number	49
Number of pages	10
Journal	Scientific Data
Volume	8
Issue number	1
Early online date	8 Feb 2021
DOIs	https://doi.org/10.1038/s41597-021-00808-y
Publication status	Published - Dec 2021

Bibliographical note

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© 2021, The Author(s).

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Copyright 2021 Elsevier B.V., All rights reserved.

ASJC Scopus subject areas

Statistics and Probability
Information Systems
Education
Computer Science Applications
Statistics, Probability and Uncertainty
Library and Information Sciences

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SaarimäkiL2021ManuallyFinal published version, 1.55 MBLicence: Creative Commons: Attribution (CC BY)

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AU - Lynch, Iseult

AU - Papadiamantis, Anastasios G.

AU - Tsoumanis, Andreas

AU - Melagraki, Georgia

AU - Afantitis, Antreas

AU - Serra, Angela

AU - Greco, Dario

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Manually curated transcriptomics data collection for toxicogenomic assessment of engineered nanomaterials

Abstract

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