Management of fatigue with physical activity and behavioural change support in vasculitis: a feasibility study

Research output: Contribution to journalArticlepeer-review

Standard

Management of fatigue with physical activity and behavioural change support in vasculitis : a feasibility study. / Harper, Lorraine; Hewitt, Catherine; Litchfield, Ian; Morgan, Matthew; Chanouzas, Dimitrios; Caulfield, Hollie; Coughlan, Linda ; Dean, Caroline ; Fletcher, Kate; Cramp, Fiona ; Greenfield, Sheila; Rowland, Natalie; Jowett, Sue; Kodabuckus, Shalela ; Tearne, Sarah; Sehmi, Sukhi; Edwardson, Charlotte ; Dawkins, Nathan P ; Daley, Amanda.

In: Rheumatology, 22.01.2021.

Research output: Contribution to journalArticlepeer-review

Harvard

APA

Vancouver

Author

Harper, Lorraine ; Hewitt, Catherine ; Litchfield, Ian ; Morgan, Matthew ; Chanouzas, Dimitrios ; Caulfield, Hollie ; Coughlan, Linda ; Dean, Caroline ; Fletcher, Kate ; Cramp, Fiona ; Greenfield, Sheila ; Rowland, Natalie ; Jowett, Sue ; Kodabuckus, Shalela ; Tearne, Sarah ; Sehmi, Sukhi ; Edwardson, Charlotte ; Dawkins, Nathan P ; Daley, Amanda. / Management of fatigue with physical activity and behavioural change support in vasculitis : a feasibility study. In: Rheumatology. 2021.

Bibtex

@article{b5fd088a7e0448cc811280e15867313d,
title = "Management of fatigue with physical activity and behavioural change support in vasculitis: a feasibility study",
abstract = "Objective: Patients with ANCA associated vasculitis (AAV) experience high levels of fatigue, despite disease remission. This study assessed the feasibility and acceptability of a definitive randomised controlled trial of a behavioural-based physical activity intervention to support fatigue self-management in AAV patients.Methods: AAV patients in disease remission with fatigue (Multidimensional Fatigue Inventory-20 general fatigue domain≥14) were randomly allocated to intervention or standard care in this single-centre open-label randomised controlled feasibility study. The intervention lasted 12 weeks and comprised eight face-to-face physical activity sessions with a facilitator and 12 weekly telephone calls. Participants were encouraged to monitor their physical activity using a tracker device (Fitbit). Standard care involved sign-posting to fatigue websites. The primary outcome was feasibility of a phase III trial assessed against three stop-go traffic light criteria, (recruitment, intervention adherence and study withdrawal). A qualitative study assessed participant views about the intervention.Results: 248 patients were screened and 134 were eligible to participate (54%). Stop-go criteria were amber for recruitment; 43/134 (32%, 95% CI 24-40) eligible participants randomised, amber for adherence; 73% of participants attended all eight physical activity sessions, but only 11/22 (50%, 95% CI 29-71%) completed the intervention as per the intended schedule, and green for study withdrawal; 2/43 participants withdrew before 24 weeks (5%, 95% CI 0-11). Qualitative results suggested the intervention was acceptable.Conclusion: This study suggests a behavioural-based physical activity intervention targeting fatigue self-management was acceptable to patients with AAV, although recruitment and protocol adherence will need modification prior to a definitive trial. Clinical Trial Registration Number: ISRCTN11929227.",
keywords = "ANCA-associated vasculitis, fatigue, feasibility study, physical activity, behavioural change support",
author = "Lorraine Harper and Catherine Hewitt and Ian Litchfield and Matthew Morgan and Dimitrios Chanouzas and Hollie Caulfield and Linda Coughlan and Caroline Dean and Kate Fletcher and Fiona Cramp and Sheila Greenfield and Natalie Rowland and Sue Jowett and Shalela Kodabuckus and Sarah Tearne and Sukhi Sehmi and Charlotte Edwardson and Dawkins, {Nathan P} and Amanda Daley",
year = "2021",
month = jan,
day = "22",
doi = "10.1093/rheumatology/keaa890",
language = "English",
journal = "Rheumatology",
issn = "1462-0324",
publisher = "Oxford University Press",

}

RIS

TY - JOUR

T1 - Management of fatigue with physical activity and behavioural change support in vasculitis

T2 - a feasibility study

AU - Harper, Lorraine

AU - Hewitt, Catherine

AU - Litchfield, Ian

AU - Morgan, Matthew

AU - Chanouzas, Dimitrios

AU - Caulfield, Hollie

AU - Coughlan, Linda

AU - Dean, Caroline

AU - Fletcher, Kate

AU - Cramp, Fiona

AU - Greenfield, Sheila

AU - Rowland, Natalie

AU - Jowett, Sue

AU - Kodabuckus, Shalela

AU - Tearne, Sarah

AU - Sehmi, Sukhi

AU - Edwardson, Charlotte

AU - Dawkins, Nathan P

AU - Daley, Amanda

PY - 2021/1/22

Y1 - 2021/1/22

N2 - Objective: Patients with ANCA associated vasculitis (AAV) experience high levels of fatigue, despite disease remission. This study assessed the feasibility and acceptability of a definitive randomised controlled trial of a behavioural-based physical activity intervention to support fatigue self-management in AAV patients.Methods: AAV patients in disease remission with fatigue (Multidimensional Fatigue Inventory-20 general fatigue domain≥14) were randomly allocated to intervention or standard care in this single-centre open-label randomised controlled feasibility study. The intervention lasted 12 weeks and comprised eight face-to-face physical activity sessions with a facilitator and 12 weekly telephone calls. Participants were encouraged to monitor their physical activity using a tracker device (Fitbit). Standard care involved sign-posting to fatigue websites. The primary outcome was feasibility of a phase III trial assessed against three stop-go traffic light criteria, (recruitment, intervention adherence and study withdrawal). A qualitative study assessed participant views about the intervention.Results: 248 patients were screened and 134 were eligible to participate (54%). Stop-go criteria were amber for recruitment; 43/134 (32%, 95% CI 24-40) eligible participants randomised, amber for adherence; 73% of participants attended all eight physical activity sessions, but only 11/22 (50%, 95% CI 29-71%) completed the intervention as per the intended schedule, and green for study withdrawal; 2/43 participants withdrew before 24 weeks (5%, 95% CI 0-11). Qualitative results suggested the intervention was acceptable.Conclusion: This study suggests a behavioural-based physical activity intervention targeting fatigue self-management was acceptable to patients with AAV, although recruitment and protocol adherence will need modification prior to a definitive trial. Clinical Trial Registration Number: ISRCTN11929227.

AB - Objective: Patients with ANCA associated vasculitis (AAV) experience high levels of fatigue, despite disease remission. This study assessed the feasibility and acceptability of a definitive randomised controlled trial of a behavioural-based physical activity intervention to support fatigue self-management in AAV patients.Methods: AAV patients in disease remission with fatigue (Multidimensional Fatigue Inventory-20 general fatigue domain≥14) were randomly allocated to intervention or standard care in this single-centre open-label randomised controlled feasibility study. The intervention lasted 12 weeks and comprised eight face-to-face physical activity sessions with a facilitator and 12 weekly telephone calls. Participants were encouraged to monitor their physical activity using a tracker device (Fitbit). Standard care involved sign-posting to fatigue websites. The primary outcome was feasibility of a phase III trial assessed against three stop-go traffic light criteria, (recruitment, intervention adherence and study withdrawal). A qualitative study assessed participant views about the intervention.Results: 248 patients were screened and 134 were eligible to participate (54%). Stop-go criteria were amber for recruitment; 43/134 (32%, 95% CI 24-40) eligible participants randomised, amber for adherence; 73% of participants attended all eight physical activity sessions, but only 11/22 (50%, 95% CI 29-71%) completed the intervention as per the intended schedule, and green for study withdrawal; 2/43 participants withdrew before 24 weeks (5%, 95% CI 0-11). Qualitative results suggested the intervention was acceptable.Conclusion: This study suggests a behavioural-based physical activity intervention targeting fatigue self-management was acceptable to patients with AAV, although recruitment and protocol adherence will need modification prior to a definitive trial. Clinical Trial Registration Number: ISRCTN11929227.

KW - ANCA-associated vasculitis

KW - fatigue

KW - feasibility study

KW - physical activity

KW - behavioural change support

U2 - 10.1093/rheumatology/keaa890

DO - 10.1093/rheumatology/keaa890

M3 - Article

JO - Rheumatology

JF - Rheumatology

SN - 1462-0324

ER -