Management of Chronic Hepatitis B in Children

Research output: Contribution to journalReview article

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Management of Chronic Hepatitis B in Children. / Shah, U; Kelly, Deirdre; Chang, MH; Fujisawa, T; Heller, S; Gonzalez-Peralta, RP; Jara, P; Mieli-Vergani, G; Mohan, N; Murray, KF.

In: Journal of Pediatric Gastroenterology and Nutrition, Vol. 48, No. 4, 01.04.2009, p. 399-404.

Research output: Contribution to journalReview article

Harvard

Shah, U, Kelly, D, Chang, MH, Fujisawa, T, Heller, S, Gonzalez-Peralta, RP, Jara, P, Mieli-Vergani, G, Mohan, N & Murray, KF 2009, 'Management of Chronic Hepatitis B in Children', Journal of Pediatric Gastroenterology and Nutrition, vol. 48, no. 4, pp. 399-404. https://doi.org/10.1097/MPG.0b013e318197196e

APA

Shah, U., Kelly, D., Chang, MH., Fujisawa, T., Heller, S., Gonzalez-Peralta, RP., Jara, P., Mieli-Vergani, G., Mohan, N., & Murray, KF. (2009). Management of Chronic Hepatitis B in Children. Journal of Pediatric Gastroenterology and Nutrition, 48(4), 399-404. https://doi.org/10.1097/MPG.0b013e318197196e

Vancouver

Shah U, Kelly D, Chang MH, Fujisawa T, Heller S, Gonzalez-Peralta RP et al. Management of Chronic Hepatitis B in Children. Journal of Pediatric Gastroenterology and Nutrition. 2009 Apr 1;48(4):399-404. https://doi.org/10.1097/MPG.0b013e318197196e

Author

Shah, U ; Kelly, Deirdre ; Chang, MH ; Fujisawa, T ; Heller, S ; Gonzalez-Peralta, RP ; Jara, P ; Mieli-Vergani, G ; Mohan, N ; Murray, KF. / Management of Chronic Hepatitis B in Children. In: Journal of Pediatric Gastroenterology and Nutrition. 2009 ; Vol. 48, No. 4. pp. 399-404.

Bibtex

@article{471944dd726e4aff8c48a569fb28b0d6,
title = "Management of Chronic Hepatitis B in Children",
abstract = "Hepatitis B virus (HBV) infection is a worldwide problem and can cause acute liver failure, acute hepatitis, chronic hepatitis, liver cirrhosis, and liver cancer. In areas of high prevalence such as in Asia, Africa, southern Europe, and Latin America, the hepatitis B surface antigen positive rate ranges from 2% to 20%. In endemic areas, HBV infection occurs mainly during infancy and early childhood. Mother-to-infant transmission accounts for approximately half of the chronic HBV infections. In contrast to infection in adults, HBV infection during early childhood results in a much higher rate of persistent infection and long-term serious complications such as liver cirrhosis and HCC. Three phases of chronic hepatitis B have been identified: the immune-tolerant phase, the immune-active phase, and the inactive hepatitis B phase. These phases of infection are characterized by variations in viral replication, hepatic inflammation, spontaneous clearance, and response to antiviral therapy. The optimal goal of antiviral therapy for chronic HBV infection is to eradicate HBV and to prevent its related liver complications. However, due to the limited effect of available therapies in viral eradication, the goal of treatment is to reduce viral replication, to minimize liver injury, and to reduce infectivity. In this review the current recommendations for monitoring and treating chronic HBV infection in children are reviewed. JPGN 48:399-404, 2009.",
keywords = "Viral hepatitis, Pediatrics, Chronic hepatitis B virus",
author = "U Shah and Deirdre Kelly and MH Chang and T Fujisawa and S Heller and RP Gonzalez-Peralta and P Jara and G Mieli-Vergani and N Mohan and KF Murray",
year = "2009",
month = apr,
day = "1",
doi = "10.1097/MPG.0b013e318197196e",
language = "English",
volume = "48",
pages = "399--404",
journal = "Journal of Pediatric Gastroenterology and Nutrition",
issn = "0277-2116",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

RIS

TY - JOUR

T1 - Management of Chronic Hepatitis B in Children

AU - Shah, U

AU - Kelly, Deirdre

AU - Chang, MH

AU - Fujisawa, T

AU - Heller, S

AU - Gonzalez-Peralta, RP

AU - Jara, P

AU - Mieli-Vergani, G

AU - Mohan, N

AU - Murray, KF

PY - 2009/4/1

Y1 - 2009/4/1

N2 - Hepatitis B virus (HBV) infection is a worldwide problem and can cause acute liver failure, acute hepatitis, chronic hepatitis, liver cirrhosis, and liver cancer. In areas of high prevalence such as in Asia, Africa, southern Europe, and Latin America, the hepatitis B surface antigen positive rate ranges from 2% to 20%. In endemic areas, HBV infection occurs mainly during infancy and early childhood. Mother-to-infant transmission accounts for approximately half of the chronic HBV infections. In contrast to infection in adults, HBV infection during early childhood results in a much higher rate of persistent infection and long-term serious complications such as liver cirrhosis and HCC. Three phases of chronic hepatitis B have been identified: the immune-tolerant phase, the immune-active phase, and the inactive hepatitis B phase. These phases of infection are characterized by variations in viral replication, hepatic inflammation, spontaneous clearance, and response to antiviral therapy. The optimal goal of antiviral therapy for chronic HBV infection is to eradicate HBV and to prevent its related liver complications. However, due to the limited effect of available therapies in viral eradication, the goal of treatment is to reduce viral replication, to minimize liver injury, and to reduce infectivity. In this review the current recommendations for monitoring and treating chronic HBV infection in children are reviewed. JPGN 48:399-404, 2009.

AB - Hepatitis B virus (HBV) infection is a worldwide problem and can cause acute liver failure, acute hepatitis, chronic hepatitis, liver cirrhosis, and liver cancer. In areas of high prevalence such as in Asia, Africa, southern Europe, and Latin America, the hepatitis B surface antigen positive rate ranges from 2% to 20%. In endemic areas, HBV infection occurs mainly during infancy and early childhood. Mother-to-infant transmission accounts for approximately half of the chronic HBV infections. In contrast to infection in adults, HBV infection during early childhood results in a much higher rate of persistent infection and long-term serious complications such as liver cirrhosis and HCC. Three phases of chronic hepatitis B have been identified: the immune-tolerant phase, the immune-active phase, and the inactive hepatitis B phase. These phases of infection are characterized by variations in viral replication, hepatic inflammation, spontaneous clearance, and response to antiviral therapy. The optimal goal of antiviral therapy for chronic HBV infection is to eradicate HBV and to prevent its related liver complications. However, due to the limited effect of available therapies in viral eradication, the goal of treatment is to reduce viral replication, to minimize liver injury, and to reduce infectivity. In this review the current recommendations for monitoring and treating chronic HBV infection in children are reviewed. JPGN 48:399-404, 2009.

KW - Viral hepatitis

KW - Pediatrics

KW - Chronic hepatitis B virus

U2 - 10.1097/MPG.0b013e318197196e

DO - 10.1097/MPG.0b013e318197196e

M3 - Review article

C2 - 19322053

VL - 48

SP - 399

EP - 404

JO - Journal of Pediatric Gastroenterology and Nutrition

JF - Journal of Pediatric Gastroenterology and Nutrition

SN - 0277-2116

IS - 4

ER -