Making sense of low oxygen sensing

Research output: Contribution to journalArticlepeer-review


  • Julia Bailey-Serres
  • Takeshi Fukao
  • Michael J Holdsworth
  • Seung Cho Lee
  • Francesco Licausi
  • Pierdomenico Perata
  • Laurentius A C J Voesenek
  • Joost T van Dongen

Colleges, School and Institutes


Plant-specific group VII Ethylene Response Factor (ERF) transcription factors have emerged as pivotal regulators of flooding and low oxygen responses. In rice (Oryza sativa), these proteins regulate contrasting strategies of flooding survival. Recent studies on Arabidopsis thaliana group VII ERFs show they are stabilized under hypoxia but destabilized under oxygen-replete conditions via the N-end rule pathway of targeted proteolysis. Oxygen-dependent sequestration at the plasma membrane maintains at least one of these proteins, RAP2.12, under normoxia. Remarkably, SUB1A, the rice group VII ERF that enables prolonged submergence tolerance, appears to evade oxygen-regulated N-end rule degradation. We propose that the turnover of group VII ERFs is of ecological relevance in wetland species and might be manipulated to improve flood tolerance of crops.

Bibliographic note

Copyright © 2011 Elsevier Ltd. All rights reserved.


Original languageEnglish
Pages (from-to)129-138
Number of pages10
JournalTrends in Plant Science
Issue number3
Early online date24 Jan 2012
Publication statusPublished - Mar 2012


  • Animals, Arabidopsis, Arabidopsis Proteins, Floods, Humans, Oxygen, Stress, Physiological, Wetlands