Making medicines baby size: the challenges in bridging the formulation gap in neonatal medicine
Research output: Contribution to journal › Review article › peer-review
Colleges, School and Institutes
- School of Pharmacy, Royal College of Surgeons in Ireland, 111 St Stephens Green Dublin 2, Ireland. firstname.lastname@example.org.
- 14 Tailors, Bishops Stortford CM23 4FQ, UK. email@example.com.
- School of Pharmacy, Royal College of Surgeons in Ireland, 111 St Stephens Green Dublin 2, Ireland. firstname.lastname@example.org.
- University of Birmingham
- University College London
- Chiesi Farmaceutici S.p.A. Largo Francesco Belloli 11/A-43122 Parma, Italy. email@example.com.
- Chiesi Farmaceutici S.p.A. Largo Francesco Belloli 11/A-43122 Parma, Italy. firstname.lastname@example.org.
- Department of Women's and Children's Health, University of Liverpool, Liverpool Women's Hospital, Liverpool L8 7SS, UK. email@example.com.
The development of age-appropriate formulations should focus on dosage forms that can deliver variable yet accurate doses that are safe and acceptable to the child, are matched to his/her development and ability, and avoid medication errors. However, in the past decade, the medication needs of neonates have largely been neglected. The aim of this review is to expand on what differentiates the needs of preterm and term neonates from those of the older paediatric subsets, in terms of environment of care, ability to measure and administer the dose (from the perspective of the patient and carer, the routes of administration, the device and the product), neonatal biopharmaceutics and regulatory challenges. This review offers insight into those challenges posed by the formulation of medicinal products for neonatal patients in order to support the development of clinically relevant products.
|Number of pages||32|
|Journal||International Journal of Molecular Sciences|
|Publication status||Published - 31 May 2019|
- neonates, formulation, product development, formulation development, oral, parenteral, topical, inhaled, intra nasal, biopharmaceutics, administration, excipient, NICU, device, medication error, dosage form