Major features of immunesenescence, including reduced thymic output, are ameliorated by high levels of physical activity in adulthood

Research output: Contribution to journalArticle

Authors

Colleges, School and Institutes

External organisations

  • MRC-Arthritis Research UK Centre for Musculoskeletal Ageing Research, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.
  • King's College London
  • NIHR Biomedical Research Centre in Inflammation, University Hospital Birmingham, Birmingham, UK.

Abstract

It is widely accepted that aging is accompanied by remodelling of the immune system including thymic atrophy and increased frequency of senescent T cells, leading to immune compromise. However, physical activity, which influences immunity but declines dramatically with age, is not considered in this literature. We assessed immune profiles in 125 adults (55-79 years) who had maintained a high level of physical activity (cycling) for much of their adult lives, 75 age-matched older adults and 55 young adults not involved in regular exercise. The frequency of naïve T cells and recent thymic emigrants (RTE) were both higher in cyclists compared with inactive elders, and RTE frequency in cyclists was no different to young adults. Compared with their less active counterparts, the cyclists had significantly higher serum levels of the thymoprotective cytokine IL-7 and lower IL-6, which promotes thymic atrophy. Cyclists also showed additional evidence of reduced immunesenescence, namely lower Th17 polarization and higher B regulatory cell frequency than inactive elders. Physical activity did not protect against all aspects of immunesenescence: CD28-veCD57+vesenescent CD8 T-cell frequency did not differ between cyclists and inactive elders. We conclude that many features of immunesenescence may be driven by reduced physical activity with age.

Details

Original languageEnglish
Article numbere12750
JournalAging Cell
Volume17
Issue number2
Early online date8 Mar 2018
Publication statusPublished - Apr 2018

Keywords

  • immunescence, inflammation, interleukin-7, physical activity, thymic output