Magnetoencephalography in the study of epilepsy and consciousness

Elaine Foley; Antonella Cerquiglini; Andrea Cavanna; Mable Angela Nakubulwa; Paul Lawrence Furlong; Caroline Witton; Stefano Seri

doi:10.1016/j.yebeh.2013.09.005

Magnetoencephalography in the study of epilepsy and consciousness

Elaine Foley, Antonella Cerquiglini, Andrea Cavanna, Mable Angela Nakubulwa, Paul Lawrence Furlong, Caroline Witton, Stefano Seri

Birmingham Medical School

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Abstract

The neural bases of altered consciousness in patients with epilepsy during seizures and at rest have raised significant interest in the last decade. This exponential growth has been supported by the parallel development of techniques and methods to investigate brain function noninvasively with unprecedented spatial and temporal resolution. In this article, we review the contribution of magnetoencephalography to deconvolve the bioelectrical changes associated with impaired consciousness during seizures. We use data collected from a patient with refractory absence seizures to discuss how spike–wave discharges are associated with perturbations in optimal connectivity within and between brain regions and discuss indirect evidence to suggest that this phenomenon might explain the cognitive deficits experienced during prolonged 3/s spike–wave discharges.

Original language	English
Pages (from-to)	38-42
Journal	Epilepsy & Behavior
Volume	30
Early online date	7 Oct 2013
DOIs	https://doi.org/10.1016/j.yebeh.2013.09.005
Publication status	Published - 1 Jan 2014

Keywords

Magnetoencephalography
Epilepsy
Connectivity
Phase lag index
Absence seizures

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10.1016/j.yebeh.2013.09.005

Cavanna_Magnetoencephalography_Epilepsy_Behavior_2014
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abstract = "The neural bases of altered consciousness in patients with epilepsy during seizures and at rest have raised significant interest in the last decade. This exponential growth has been supported by the parallel development of techniques and methods to investigate brain function noninvasively with unprecedented spatial and temporal resolution. In this article, we review the contribution of magnetoencephalography to deconvolve the bioelectrical changes associated with impaired consciousness during seizures. We use data collected from a patient with refractory absence seizures to discuss how spike–wave discharges are associated with perturbations in optimal connectivity within and between brain regions and discuss indirect evidence to suggest that this phenomenon might explain the cognitive deficits experienced during prolonged 3/s spike–wave discharges.",

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AU - Cerquiglini, Antonella

AU - Cavanna, Andrea

AU - Nakubulwa, Mable Angela

AU - Furlong, Paul Lawrence

AU - Witton, Caroline

AU - Seri, Stefano

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KW - Magnetoencephalography

KW - Epilepsy

KW - Connectivity

KW - Phase lag index

KW - Absence seizures

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JO - Epilepsy & Behavior

JF - Epilepsy & Behavior

ER -

Magnetoencephalography in the study of epilepsy and consciousness

Abstract

Keywords

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