Magnetic stimulation of the dorsolateral prefrontal cortex dissociates fragile visual short-term memory from visual working memory

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Magnetic stimulation of the dorsolateral prefrontal cortex dissociates fragile visual short-term memory from visual working memory. / Sligte, Ilja G; Wokke, Martijn E; Tesselaar, Johannes P; Scholte, H Steven; Lamme, Victor A F.

In: Neuropsychologia, Vol. 49, No. 6, 05.2011, p. 1578-88.

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Sligte, Ilja G ; Wokke, Martijn E ; Tesselaar, Johannes P ; Scholte, H Steven ; Lamme, Victor A F. / Magnetic stimulation of the dorsolateral prefrontal cortex dissociates fragile visual short-term memory from visual working memory. In: Neuropsychologia. 2011 ; Vol. 49, No. 6. pp. 1578-88.

Bibtex

@article{90a86635816044438ef56080c79183e4,
title = "Magnetic stimulation of the dorsolateral prefrontal cortex dissociates fragile visual short-term memory from visual working memory",
abstract = "To guide our behavior in successful ways, we often need to rely on information that is no longer in view, but maintained in visual short-term memory (VSTM). While VSTM is usually broken down into iconic memory (brief and high-capacity store) and visual working memory (sustained, yet limited-capacity store), recent studies have suggested the existence of an additional and intermediate form of VSTM that depends on activity in extrastriate cortex. In previous work, we have shown that this fragile form of VSTM can be dissociated from iconic memory. In the present study, we provide evidence that fragile VSTM is different from visual working memory as magnetic stimulation of the right dorsolateral prefrontal cortex (DLPFC) disrupts visual working memory, while leaving fragile VSTM intact. In addition, we observed that people with high DLPFC activity had superior working memory capacity compared to people with low DLPFC activity, and only people with high DLPFC activity really showed a reduction in working memory capacity in response to magnetic stimulation. Altogether, this study shows that VSTM consists of three stages that have clearly different characteristics and rely on different neural structures. On the methodological side, we show that it is possible to predict individual susceptibility to magnetic stimulation based on functional MRI activity.",
keywords = "Adult, Discrimination (Psychology), Female, Functional Laterality, Humans, Magnetic Resonance Imaging, Male, Memory, Short-Term, Prefrontal Cortex, Reference Values, Transcranial Magnetic Stimulation, Visual Perception",
author = "Sligte, {Ilja G} and Wokke, {Martijn E} and Tesselaar, {Johannes P} and Scholte, {H Steven} and Lamme, {Victor A F}",
note = "Crown Copyright {\textcopyright} 2010. Published by Elsevier Ltd. All rights reserved.",
year = "2011",
month = may,
doi = "10.1016/j.neuropsychologia.2010.12.010",
language = "English",
volume = "49",
pages = "1578--88",
journal = "Neuropsychologia",
issn = "0028-3932",
publisher = "Elsevier",
number = "6",

}

RIS

TY - JOUR

T1 - Magnetic stimulation of the dorsolateral prefrontal cortex dissociates fragile visual short-term memory from visual working memory

AU - Sligte, Ilja G

AU - Wokke, Martijn E

AU - Tesselaar, Johannes P

AU - Scholte, H Steven

AU - Lamme, Victor A F

N1 - Crown Copyright © 2010. Published by Elsevier Ltd. All rights reserved.

PY - 2011/5

Y1 - 2011/5

N2 - To guide our behavior in successful ways, we often need to rely on information that is no longer in view, but maintained in visual short-term memory (VSTM). While VSTM is usually broken down into iconic memory (brief and high-capacity store) and visual working memory (sustained, yet limited-capacity store), recent studies have suggested the existence of an additional and intermediate form of VSTM that depends on activity in extrastriate cortex. In previous work, we have shown that this fragile form of VSTM can be dissociated from iconic memory. In the present study, we provide evidence that fragile VSTM is different from visual working memory as magnetic stimulation of the right dorsolateral prefrontal cortex (DLPFC) disrupts visual working memory, while leaving fragile VSTM intact. In addition, we observed that people with high DLPFC activity had superior working memory capacity compared to people with low DLPFC activity, and only people with high DLPFC activity really showed a reduction in working memory capacity in response to magnetic stimulation. Altogether, this study shows that VSTM consists of three stages that have clearly different characteristics and rely on different neural structures. On the methodological side, we show that it is possible to predict individual susceptibility to magnetic stimulation based on functional MRI activity.

AB - To guide our behavior in successful ways, we often need to rely on information that is no longer in view, but maintained in visual short-term memory (VSTM). While VSTM is usually broken down into iconic memory (brief and high-capacity store) and visual working memory (sustained, yet limited-capacity store), recent studies have suggested the existence of an additional and intermediate form of VSTM that depends on activity in extrastriate cortex. In previous work, we have shown that this fragile form of VSTM can be dissociated from iconic memory. In the present study, we provide evidence that fragile VSTM is different from visual working memory as magnetic stimulation of the right dorsolateral prefrontal cortex (DLPFC) disrupts visual working memory, while leaving fragile VSTM intact. In addition, we observed that people with high DLPFC activity had superior working memory capacity compared to people with low DLPFC activity, and only people with high DLPFC activity really showed a reduction in working memory capacity in response to magnetic stimulation. Altogether, this study shows that VSTM consists of three stages that have clearly different characteristics and rely on different neural structures. On the methodological side, we show that it is possible to predict individual susceptibility to magnetic stimulation based on functional MRI activity.

KW - Adult

KW - Discrimination (Psychology)

KW - Female

KW - Functional Laterality

KW - Humans

KW - Magnetic Resonance Imaging

KW - Male

KW - Memory, Short-Term

KW - Prefrontal Cortex

KW - Reference Values

KW - Transcranial Magnetic Stimulation

KW - Visual Perception

U2 - 10.1016/j.neuropsychologia.2010.12.010

DO - 10.1016/j.neuropsychologia.2010.12.010

M3 - Article

C2 - 21168424

VL - 49

SP - 1578

EP - 1588

JO - Neuropsychologia

JF - Neuropsychologia

SN - 0028-3932

IS - 6

ER -